PuSH - Publikationsserver des Helmholtz Zentrums München

Berk, B.* ; Rohayem, R.* ; Reiger, M. ; Klepper, L. ; Ranieri, C.* ; Gülzow, C.* ; Seide, C.* ; Worthmann, A.* ; Schölermann, A.M.* ; Rippke, F.* ; Traidl-Hoffmann, C. ; Hülpüsch, C.* ; Neumann, A.U.

270 Impact of topical corticosteroids and pH-modulating emollients on skin physiology and skin microbiome in atopic dermatitis patients.

J. Invest. Dermatol. 145, e74 - e74 (2025)
DOI
Introduction: Atopic dermatitis (AD) is an inflammatory skin disorder characterized by disrupted skin barrier, increased skin pH and elevated skin Staphylococcus aureus colonization. The complex interplay between skin microenvironment and microbiome in AD is not yet fully understood. Here we investigated the influence of topical corticosteroids (TCS) and of pH-lowering emollient on the skin physiology and microbiome in real-life AD setting. Methods: A double-blinded, placebo-controlled study was performed in 29 mild-moderate AD patients. TCS was applied for two weeks, followed by pH-lowering verum and placebo emollients on opposite bodysides for six weeks. Clinical, skin physiology and skin microbiome data was collected every 2-4 weeks. Skin microbiome composition was analyzed by 16S sequencing. Skin S. aureus absolute numbers were quantified by standardized qPCR. Results: TCS significantly lowered SCORAD in all patients, in correlation with transepidermidal water loss (TEWL) drecrease in patients with high baseline TEWL. Skin pH and hydration were not afftected by TCS. Lesional skin S. aureus abundance, both relative and absolute, significantly declined after TCS therapy in patients with hight baseline S. aureus abundance. Skin pH was significantly reduced by the pH-lowering verum, to significantly lower pH than placebo. Skin hydration was significantly increased by both verum and placebo emollients. However, S. aureus abundance increased back to baseline during both the verum and placebo emollient application, independent of the skin pH decline. Conclusions: Our findings provide valuable longitudinal data on treatment responses and microbiome dynamics in real-life setting. Topical corticosteroid therapy positively modulated the skin barrier and decreased S. aureus skin colonization with no effect on skin pH. Skin pH reduction by pH-lowering emollient did not control skin Staphylococcus aureus colonization compared to placebo. Thus, changing the skin pH might be irrelevant in balancing AD skin microbiome. Future studies should validate these findings in cohorts enriched for severe AD.
Altmetric
Weitere Metriken?
[➜Einloggen]
Zusatzinfos bearbeiten [➜Einloggen]
Publikationstyp Artikel: Journalartikel
Dokumenttyp Meeting abstract
Schlagwörter Atopic Dermatitis ; Microbiome ; Skin Barrier ; Human Skin ; Skin Care
ISSN (print) / ISBN 0022-202X
e-ISSN 1523-1747
Zeitschrift Journal of Investigative Dermatology, The
Quellenangaben Band: 145, Heft: 11, Seiten: e74 - e74 Artikelnummer: , Supplement: ,
Verlag Elsevier
Verlagsort New York, NY
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Environmental Medicine (IEM)