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Löck, S.* ; Koi, L.* ; Gurtner, K.* ; Lohaus, F.* ; Kemper, M.* ; Haim, D.* ; Tinhofer, I.* ; Kalinauskaite, G.* ; Stuschke, M.* ; Fleischmann, M.* ; Rödel, C.* ; Grosu, A.L.* ; Debus, J.* ; Belka, C. ; Combs, S.E. ; Boeke, S.* ; Baretton, G.* ; Baumann, M.* ; Krause, M.* ; Linge, A.*

Application of a preclinical 18-gene classifier to patients with locally advanced HNSCC.

Clin. Transl. Radiat. Oncol. 56:101067 (2026)
Verlagsversion Forschungsdaten DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
In a previous preclinical trial on human HNSCC xenografts, 18 genes were predictive for adding cetuximab to fractionated radiotherapy. Here, we apply the corresponding 18-gene classifier to two HNSCC patient cohorts treated with combined radiochemotherapy (without cetuximab). We show that the classifier is related to EGFR expression and stratifies patients for loco-regional control (LRC) in both cohorts.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Cetuximab ; Egfr ; Gene Signature ; Head And Neck Cancer ; Outcome Prediction ; Xenograft Models; Squamous-cell Carcinoma; Good Prognosis Subgroups; Postoperative Radiochemotherapy; Advanced Head; Mesenchymal Transition; Combined Radiotherapy; Radiation-therapy; Marker Expression; Egfr-inhibition; Tumor-control
ISSN (print) / ISBN 2405-6308
e-ISSN 2405-6308
Zeitschrift Clinical and translational radiation oncology
Quellenangaben Band: 56, Heft: , Seiten: , Artikelnummer: 101067 Supplement: ,
Verlag Elsevier
Verlagsort Amsterdam
Begutachtungsstatus Peer reviewed
Institut(e) Translational Metabolic Oncology (IDC-TMO)
Institute of Radiation Medicine (IRM)