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Maskarinec, G.* ; Klapp, R.* ; Nöthlings, U.* ; Schulze, M.B.* ; Bamberg, F.* ; Machann, J. ; Schlesinger, S.* ; Leitzmann, M.* ; Sedlmeier, A.* ; Bohmann, P.* ; Rospleszcz, S.* ; Nattenmüller, J.* ; Haueise, T. ; Steindorf, K.* ; Niendorf, T.* ; Schlett, C.L.* ; Greiser, K.H.* ; Panreck, L.* ; Linseisen, J.* ; Conzen, C.A.* ; Gastell, S.* ; Schikowski, T.* ; Völzke, H.* ; Bülow, R.* ; Peters, A. ; Niedermayer, F. ; Kaaks, R.* ; Becher, H.* ; Karch, A.* ; Berger, K.* ; Keil, T.* ; Krist, L.* ; Hoffmeister, M.* ; Mons, U.* ; Schmidt, B.* ; Stang, A.* ; Mikolajczyk, R.* ; Kluttig, A.* ; Lieb, W.* ; Övermöhle, C.* ; Hebestreit, A.* ; Günther, K.* ; Harth, V.* ; Obi, N.* ; Castell, S.* ; Kettlitz, R.* ; Nimptsch, K.* ; Pischon, T.*

Association of a lifestyle risk index with visceral and subcutaneous adipose tissue in the German National Cohort (NAKO).

Obesity, DOI: 10.1002/oby.70071 (2025)
Verlagsversion Forschungsdaten DOI PMC
Open Access Hybrid
Creative Commons Lizenzvertrag
OBJECTIVE: This cross-sectional study examined a Lifestyle Risk Factor Index (LSRI) in relation to adiposity measures including visceral adipose tissue (VAT) in the German National Cohort (NAKO). METHODS: Based on self-reports at baseline among 30,920 of > 205,000 NAKO eligible participants with magnetic resonance imaging (MRI) scans, one point each for not smoking, adhering to ≥ 3/7 diet recommendations, consuming ≤ 1 (women)/≤ 2 (men) alcoholic drinks/day, and ≥ 150 min/week physical activity was assigned. VAT volume, obtained from whole-body MRI at 3T, was analyzed by deep learning-based image segmentation. General linear models estimated adjusted geometric mean adiposity measures by LSRI and stratified analyses by sex and BMI. RESULTS: Of 18,508 participants aged 48.2 ± 12.2 years, the respective proportions for 0/1, 2, 3, and 4 LSRI points were 7%, 24%, 51%, and 18%. Participants with LSRI scores of 4 versus 0/1 had lower adjusted geometric mean volumes of VAT (2.3; 95% CI 2.2, 2.3 vs. 3.0; 95% CI 2.9, 3.1 L). These differences were slightly attenuated after adding BMI. This association was weaker for individuals with obesity than normal/overweight. CONCLUSION: A combination of lifestyle factors appears to be associated with lower VAT volume, but an elevated BMI may have a greater influence on VAT accumulation than lifestyle behaviors alone.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Body Fat Distribution ; Cohort Study ; Lifestyle Behaviors ; Obesity; Breast-cancer Risk; Physical-activity; Obesity; Exercise; Smoking; Diet
ISSN (print) / ISBN 1930-7381
e-ISSN 1930-739X
Zeitschrift Obesity
Verlag Wiley
Verlagsort 111 River St, Hoboken 07030-5774, Nj Usa
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Diabetes Research and Metabolic Diseases (IDM)
Institute of Epidemiology (EPI)
Förderungen Helmholtz Association
Leibniz Association
Stiftung Charité