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Thomas, S.R.* ; de Andrade Querino, A.L.* ; Moreno-Alcántar, G.* ; Tran, T.* ; Rodríguez-Prieto, T.* ; Qian, S.* ; Di Giuseppe, D. ; Anzenhofer,P. ; Ntziachristos, V. ; Silva, H.* ; Somoza, V.* ; Fischer, R.A.* ; Casini, A.*

Water-soluble N-heterocyclic carbene stabilized gold nanoparticles by top-down synthesis: Performance in catalysis and photoacoustic imaging.

Nanoscale, DOI: 10.1039/d5nr03709c (2025)
Verlagsversion Forschungsdaten DOI PMC
Open Access Hybrid
Creative Commons Lizenzvertrag
N-heterocyclic carbenes (NHCs) have emerged as effective capping ligands for gold nanoparticles (AuNPs), offering improved stability and flexibility compared to sulfur-based alternatives. Two synthetic approaches, 'bottom-up' (BU) and 'top-down' (TD), have been described; however, comparative studies remain scarce. Herein, we report the TD-synthesized water-soluble NHC-stabilized AuNPs (NHC@AuNPs) for catalysis in water and biomedical applications, exhibiting exceptional stability in physiologically relevant conditions. Further, the catalytic ability of TD-NPs in model reactions was compared to their BU counterparts featuring the same NHC ligands. In detail, the catalysts were tested for the reduction of 4-nitrophenol and resazurin, as well as for the biomimetic oxidation of 3,3,5,5-tetramethylbenzidine (TMB) in aqueous conditions. The TD-NPs also showed distinct advantages over the BU NPs as contrast agents in photoacoustic imaging (PAI), further highlighting the differences between the two families of colloids.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Oxidation
ISSN (print) / ISBN 2040-3364
e-ISSN 2040-3372
Zeitschrift Nanoscale
Verlag Royal Society of Chemistry (RSC)
Verlagsort Cambridge
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Biological and Medical Imaging (IBMI)
Förderungen CNPq
Deutsche Forschungs-Gemeinschaft (DFG, German Research Foundation) under Germany's Excellence Strategy
Ministry of Universities of Spain
Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior - Brasil (CAPES)
FWF (Austrian Science Fund)
TUM