PuSH - Publikationsserver des Helmholtz Zentrums München

Export: TXT Text RIS Endnote (RIS) BIB BibTeX
Hartung, T.J.* ; Steigerwald, F.* ; Romanello, A.* ; Kodde, C.* ; Endres, M.* ; Frank, S.* ; Heuschmann, P.* ; Koehler, P.* ; Krohn, S.* ; Pape, D.* ; Schaller, J.* ; Stöcklein, S.* ; Vadász, I.* ; Vehreschild, J.* ; Witzenrath, M.* ; Zöller, T.* ; Finke, C.* ; NAPKON Study Group (Kraus, M.) ; NAPKON Study Group (Lorenz-Depiereux, B.)

Post-COVID fatigue is associated with reduced cortical thickness after hospitalization.

Ann. Clin. Transl. Neurol., DOI: 10.1002/acn3.70260 (2025)
Verlagsversion Forschungsdaten DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
OBJECTIVE: Neuropsychiatric symptoms are among the most prevalent sequelae of COVID-19, particularly among hospitalized patients. Recent research has identified volumetric brain changes associated with COVID-19. However, it currently remains poorly understood how brain changes relate to post-COVID fatigue and cognitive deficits. We, therefore, aimed to assess structural brain changes after hospitalization for COVID-19 and their associations with cognitive performance and fatigue. METHODS: We analyzed data from n = 57 patients previously hospitalized for COVID-19 (63% male, mean age 52 years) from the prospective, multicentric high-resolution platform of the German National Pandemic Cohort Network (NAPKON-HAP) and n = 57 matched healthy control participants (HC). We assessed cortical thickness and subcortical volumes in high-resolution T1-weighted MRI and their associations with cognitive performance (Montreal Cognitive Assessment) and fatigue (Fatigue Severity Scale). RESULTS: Patients exhibited statistically significant reductions of cortical thickness in parahippocampal gyri and the temporal lobe (all p[FDR-corrected] < 0.05) as well as reduced hippocampal volumes compared to HC (left, Cohen's d [95% CI] = 0.50 [0.12-0.8]; right d = 0.43 [0.05-0.80]). Higher acute COVID-19 severity was associated with reduced cortical thickness, particularly in the olfactory system. Furthermore, reduced cortical thickness of the temporal poles and the anterior and posterior cingulate gyrus was associated with more severe post-acute fatigue. INTERPRETATION: Our results identify long-lasting macrostructural brain changes after moderate to severe COVID-19 that correlate with acute disease severity and long-term fatigue. Early identification and targeted interventions for patients at risk of persistent brain changes are needed. TRIAL REGISTRATION: NAPKON-HAP is registered at clinicaltrials.gov (NCT04747366).
Impact Factor
Scopus SNIP
Altmetric
0.000
0.000
Tags
Anmerkungen
Besondere Publikation
Auf Hompepage verbergern

Zusatzinfos bearbeiten
Eigene Tags bearbeiten
Privat
Eigene Anmerkung bearbeiten
Privat
Auf Publikationslisten für
Homepage nicht anzeigen
Als besondere Publikation
markieren
Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Covid‐19 ; Cognitive Dysfunction ; Fatigue ; Magnetic Resonance Imaging ; Post‐acute Covid‐19 Syndrome
Sprache englisch
Veröffentlichungsjahr 2025
HGF-Berichtsjahr 2025
ISSN (print) / ISBN 2328-9503
e-ISSN 2328-9503
Zeitschrift Annals of Clinical and Translational Neurology
Verlag Wiley
Verlagsort Chichester [u.a.]
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Epidemiology (EPI)
POF Topic(s) 30202 - Environmental Health
Forschungsfeld(er) Genetics and Epidemiology
PSP-Element(e) G-504091-004
Förderungen Deutsche Forschungsgemeinschaft
DOI 10.1002/acn3.70260
PubMed ID 41288256
Erfassungsdatum 2025-11-26
[➜Korrektur melden]