Fluorescence molecular imaging (FMI) is becoming a powerful tool to
improve surgical precision and diagnostics. Although significant
advances have been made in imaging technology and contrast agents,
debate continues regarding suitable standards for FMI. Standardizing all
FMI aspects is crucial for adoption in clinical procedures and routine
practice. Currently, the lack of clear-cut guidelines on FMI study
reporting complicates comparison between studies and impedes
standardization. This work presents community-driven REFLECT guidelines
for FMI study reporting for fluorescence-guided surgery and
interventions, covering preclinical, translational, and clinical
studies. It aims to improve quality of reporting, enable comparison
between studies, and enhance interpretation of results. The resulting
structured checklist encompasses all essential details for reporting on
the contrast agent, imaging device, imaging protocol, and image
processing and analysis methods. Adoption of this framework is
encouraged to enhance reproducibility and establish alignment with
standardization efforts in the field - thus fostering advancements in
FMI.