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Karfusehr, C.* ; Eder, M.* ; Yang, H.Y.* ; Beinsteiner, B. ; Jasnin, M. ; Simmel, F.C.*

Self-assembled cell-scale containers made from DNA origami membranes.

Nat. Mater., 23 (2025)
Verlagsversion Forschungsdaten DOI PMC
Open Access Hybrid
Creative Commons Lizenzvertrag
Biological compartmentalization creates and controls localized environments to ensure that chemical processes are efficient, thus enabling life's complexity and functionality. Biological systems use crystalline protein cages for nanoscale compartments, whereas larger, dynamic structures, such as vesicles and cell membranes, are formed from lipid bilayers. Although membrane-based approaches have prevailed in bottom-up synthetic biology, DNA and protein nanotechnology has focused on designing rigid cage assemblies. Here we report on the self-assembly of radially symmetric DNA origami subunits that are inspired by the structure and interactions of lipids. The formed DNA origami monolayer membranes can be readily programmed to form vesicles or hollow tubes with diameters ranging from 100 nm to over 1 μm. These DNA origami membranes represent an approach for compartmentalization that opens possibilities in bottom-up biology and cell-scale soft robotics.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Principles
Sprache englisch
Veröffentlichungsjahr 2025
HGF-Berichtsjahr 2025
ISSN (print) / ISBN 1476-1122
e-ISSN 1476-1122
Zeitschrift Nature materials
Quellenangaben Band: , Heft: , Seiten: 23 Artikelnummer: , Supplement: ,
Verlag Nature Publishing Group
Verlagsort Basingstoke
Begutachtungsstatus Peer reviewed
Institut(e) Helmholtz Pioneer Campus (HPC)
POF Topic(s) 30203 - Molecular Targets and Therapies
Forschungsfeld(er) Pioneer Campus
PSP-Element(e) G-510008-001
Förderungen
Bundesministerium fr Bildung und Forschung (Federal Ministry of Education and Research)
DOI 10.1038/s41563-025-02418-0
WOS ID 001626278100001
Scopus ID 105023210011
PubMed ID 41315785
Erfassungsdatum 2025-12-01
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