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Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Circulating levels of gut hormones in anorexia nervosa before and after short-term weight restoration.
Prog. Neuro-Psychopharmacol. Biol. Psychiatry 144:111576 (2025)
Gastrointestinal hormones such as glucagon-like peptide-1 (GLP-1), gastric inhibitory peptide (GIP), glucagon and glicentin are important regulators of appetite and glucose homeostasis. While, agonists of GLP-1 and GIP receptors are approved treatments for type 2 diabetes and obesity, their role in anorexia nervosa (AN) remains largely unknown. In this study, we measured fasting serum levels of GLP-1, GIP, glucagon, and glicentin in 80 female patients with AN before (acAN-T1) and after short-term weight restoration (acAN-T2) compared to 80 age-matched female healthy controls (HC). GIP levels were higher (42.9 %) in acAN-T1 than in HC, while GLP-1, glicentin, and glucagon showed no group differences. Additionally, acAN-T1 patients exhibited lower fasting glucose (-8.4 %) and insulin (-42.6 %) levels than HC. In acAN-T2 GIP, GLP-1, and glicentin levels decreased (-30.4 %, -9.7 %, -15,7 % respectively), with only GIP normalizing. Glucose and insulin levels increased (4.5 % and 41.4 %, respectively), although they remained lower than in HC. Importantly changes in GIP levels after short-term weight restoration negatively correlated (r = -0.279) with changes in glucose levels. Furthermore, GIP levels in acAN-T1, were positively associated with disordered eating and depressive symptoms, independent of BMI-SDS. These results reveal that GIP shows a distinct pattern of dysregulation and normalization in AN, and link GIP levels to both glucose metabolism and symptom severity in AN. Thus, our findings support the rationale for investigating GIP receptor-targeted therapies in AN.
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Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Wissenschaftlicher Artikel
Schlagwörter
Glucagon-like Peptide-1; Body-mass Index; Mixed-meal; Glucose; Children; Oxyntomodulin; Percentiles; Polypeptide; Secretion; Ghrelin
ISSN (print) / ISBN
0278-5846
e-ISSN
1878-4216
Quellenangaben
Band: 144,
Artikelnummer: 111576
Verlag
Elsevier
Verlagsort
The Boulevard, Langford Lane, Kidlington, Oxford Ox5 1gb, England
Begutachtungsstatus
Peer reviewed
Institut(e)
Institute of Pancreatic Islet Research (IPI)
Förderungen
German Ministry of Research and Education-Bundesministerium fur Bildung und Foschung (BMBF)-Deutsches Zentrum fur Diabetesforschung (DZD e.V.)
NIMH
Federal Ministry of Education and Research (Bundesministerium fur Bildung und Forschung, BMBF) as part of the German Center for Child and Adolescent Health (DZKJ)
Deutsche Forschungsgemeinschaft (DFG, German Research Foundation)
UK Medical Research Council
European Union
National Institute for Health Research (NIHR) Biomedical Research Centre at South London and Maudsley NHS Foundation Trust and King's College London
German Research Foundation
NIMH
Federal Ministry of Education and Research (Bundesministerium fur Bildung und Forschung, BMBF) as part of the German Center for Child and Adolescent Health (DZKJ)
Deutsche Forschungsgemeinschaft (DFG, German Research Foundation)
UK Medical Research Council
European Union
National Institute for Health Research (NIHR) Biomedical Research Centre at South London and Maudsley NHS Foundation Trust and King's College London
German Research Foundation