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Knauer, T.* ; Mardin, C.Y.* ; Rosenkranz, C.* ; Lucio, M. ; Hohberger, B.*

Longitudinal follow-up of macular retinal microcirculation in patients with Post-COVID Syndrome.

Invest. Ophthalmol. Vis. Sci. 66:2 (2025)
Verlagsversion
Open Access Hybrid
Purpose : Post-COVID syndrome (PCS) is a multifactorial disorder with different subgroups. Recent data suggest that a subgroup of PCS patients show an impaired capillary, retinal microcirculation, imaged by OCT-angiography (OCT-A). The present study aimed to investigate the longitudinal follow-up of macular retinal microcirculation in PCS patients compared to controls. Methods : 310 eyes of 155 subjects were recruited at the Department of Ophthalmology, University of Erlangen-Nuremberg: 142 eyes of 71 patients with PCS (39 female, 32 male; age 41.19± 11 years) and 168 eyes of 84 controls (47 female, 37 male; age 35.09±14 years). Capillary microcirculation was measured by en-face OCT-A imaging twice (Spectralis II, Heidelberg Engineering, Germany) in the macula: Vessel Density (VD; superficial vascular plexus (SVP), intermediate capillary plexus (ICP), deep capillary plexus (DCP)). PCS symptom persistency was 300±123 days at the time of visit1. Mean time of follow-up was 284 days. VD was calculated by the Erlangen-Angio tool, including an APSifyed and Bruch’s membrane opening (BMO) based analysis. A mixed model was done in such a way that each patient had multiple measurements over time and for each eye, with gender and age as covariates. The study was approved by the local ethics committee and performed in accordance to the tenets of the Declaration of Helsinki. Results : Baseline: the estimates least-squares means (LS-means) of VD were 34.5 vs 32.6 (SVP), 24.15 vs 23.6 (ICP), and 26.35 vs 26.2 (DCP) in controls vs PCS patients; LS-Mean VD of ICP (p-value =0.0387) and DCP (p-value =0.0311) were significantly reduced in PCS patients compared to controls. Follow-up analysis within PCS patients showed a VD of 30.5 vs 30.3 (SVP), 22.4 vs. 22.0 (ICP), and 23.8 vs 23.7 (DCP) at visit1 vs visit2 in patients with PCS. Mixed model analysis yielded significant effects for LS-Mean of VD of ICP between visit1 versus visit2 (p-value=0.0098) in patients with PCS. Conclusions : As capillary VD in ICP was observed to diminish further over time in patients with persistent PCS, further research is needed to understand PCS effect on retinal microvasculature.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Meeting abstract
ISSN (print) / ISBN 0146-0404
e-ISSN 1552-5783
Zeitschrift Investigative Ophthalmology & Visual Science, IOVS
Quellenangaben Band: 66, Heft: 8, Seiten: , Artikelnummer: 2 Supplement: ,
Verlag Association for Research in Vision and Ophthalmology (ARVO)
Verlagsort 12300 Twinbrook Parkway, Rockville, Md 20852-1606 Usa
Begutachtungsstatus Peer reviewed
Institut(e) Research Unit BioGeoChemistry and Analytics (BGC)