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Rapöhn, I. ; Broghammer, H. ; Hoffmann, A. ; Möhlis, K. ; Moormann, A. ; Kaczmarek, I.* ; Thor, D.* ; Großkopf, H.* ; Krieg, L.* ; Karkossa, I.* ; Schubert, K.* ; von Bergen, M.* ; Krause, K.* ; Breitfeld, J.* ; Kovacs, P.* ; Klöting, N. ; Nuwayhid, R.* ; Langer, S.* ; Ghosh, A.* ; Wolfrum, C.* ; Stumvoll, M. ; Blüher, M. ; Heiker, J.T. ; Weiner, J.*

Inhibition of adipocyte lipolysis by vaspin impairs thermoregulation in vivo.

Nat. Commun. 16:11075 (2025)
Verlagsversion Forschungsdaten DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
Altered activity of brown adipose tissue (BAT) contributes to obesity, insulin resistance, and cardiovascular disease. BAT secretes endocrine factors ("batokines") that regulate thermogenesis. We identify the serpin vaspin as a batokine that modulates adrenergic control of lipolysis and thermogenesis. Adipocyte-specific vaspin overexpression in mice reduces BAT activation and impairs thermoregulation during cold exposure or fasting. Mechanistically, vaspin binds low-density lipoprotein receptors (LRP1, LDLR, vLDLR), inhibiting adrenergic signaling and lipolysis in brown and white adipocytes by modulating phosphodiesterase activity and endocytic lipid uptake. Gene set enrichment analyses in human subcutaneous adipose tissue and in vitro studies confirm vaspin's anti-lipolytic effects in humans. Overall, vaspin emerges as a regulatory BATokine that fine-tunes BAT thermogenic activity to limit excessive energy expenditure and preserve metabolic balance.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
ISSN (print) / ISBN 2041-1723
e-ISSN 2041-1723
Zeitschrift Nature Communications
Quellenangaben Band: 16, Heft: 1, Seiten: , Artikelnummer: 11075 Supplement: ,
Verlag Nature Publishing Group
Verlagsort London
Begutachtungsstatus Peer reviewed
Institut(e) Helmholtz Institute for Metabolism, Obesity and Vascular Research (HI-MAG)