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Skerrett-Byrne, D.A. ; Ashton, L.M.* ; Nixon, B.* ; Morgan, P.J.*

Determinants of male fertility in the Western Pacific Region: Environmental, biological, and lifestyle influences.

Lancet Reg. Health-W. Pac. 65:101716 (2025)
Verlagsversion DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
Over the past half-century, global fertility rates have declined, with the Western Pacific Region (WPR) experiencing a particularly notable drop. A recent World Health Organisation-commissioned report identified the WPR as exhibiting the highest infertility prevalence at 23.2%, compared to the global average of 17.5%. While the drivers of this decline are complex, one key contributor is male infertility, yet it remains under addressed in research and policy. In this paper, we synthesise current evidence on male infertility with a focus on the WPR. Specifically, we explore environmental, biological, and demographic correlates of male infertility, examine molecular mechanisms regulating sperm function and assess the impact of lifestyle interventions. Our findings highlight significant gaps in regional evidence, advocating for targeted research and culturally tailored interventions to enhance preconception male health within the WPR. Based on this synthesis, we propose preventive strategies and evidence-based recommendations to improve male preconception health in the region.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Assisted Reproductive Technologies ; Environmental Factors ; Epigenetics ; Fertility ; Interventions ; Male Infertility ; Men's Health ; Mental Health ; Nutrition ; Paternal Preconception Health ; Physical Activity ; Sperm ; Sperm Proteomics ; Substance Use ; Transgenerational Health ; Weight Management; In-vitro Fertilization; Advanced Paternal Age; Semen Quality; Psychosocial Interventions; Infertile Couples; Pregnancy Rates; Climate-change; Air-pollution; Heat-stress; Healthy-men
ISSN (print) / ISBN 2666-6065
e-ISSN 2666-6065
Zeitschrift The Lancet Regional Health - Western Pacific
Quellenangaben Band: 65, Heft: , Seiten: , Artikelnummer: 101716 Supplement: ,
Verlag Elsevier
Verlagsort Radarweg 29, 1043 Nx Amsterdam, Netherlands
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Experimental Genetics (IEG)
Förderungen NHMRC Emerging Leadership Fellowship
National Health and Medical Research Council (NHMRC)