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Coolens, K.* ; Van der Vliet, M.* ; Van Campenhout, J.* ; Pozo, N.D.* ; Torres-Cano, A.* ; Olson, C.* ; Xu, J.* ; Lickert, H. ; Rovira, M.* ; Houbracken, I.* ; Baldan, J.* ; Real, F.X.* ; Spagnoli, F.M.* ; Rooman, I.*

ΔNP63 defines an exocrine-committed subset of murine pancreatic progenitor cells.

Cell. Mol. Gast. Hept.:101715 (2025)
Postprint DOI PMC
Open Access Gold
Cellular plasticity underpins heterogeneity in embryogenic progenitor cells and cancercells. The transcription factor deltaNp63 (ΔNp63) has been implicated in regulatingcellular plasticity in several epithelial tissues. Despite a recently established role insteering plasticity of pancreatic cancer, ΔNp63 remains unstudied in pancreaticdevelopment.Using murine single-cell sequencing data and RNA and protein in situ stainings, weassessed the spatio-temporal expression of Trp63 and ΔNP63 in the embryonic pancreas.ΔNP63 demonstrates a transient and spatially restricted expression in the multipotentpancreatic progenitor (MPP) compartment delineating pro-exocrine progenitor cells.Lineage tracing of TP63+ cells marks a subset of MPPs and descendant exocrine acinarand centro-acinar/terminal duct cells. Lack of ΔNP63 in knock-out mice leads tohypotrophic exocrine acini with reduced levels of differentiation markers.In summary, ΔNp63 confers heterogeneity within the MPP compartment, supportingexocrine cell development. These new insights in developmental plasticity have potentialimplications for pancreatic regeneration and cancer.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
ISSN (print) / ISBN 2352-345X
e-ISSN 2352-345X
Zeitschrift Cellular and Molecular Gastroenterology and Hepatology
Quellenangaben Band: , Heft: , Seiten: , Artikelnummer: 101715 Supplement: ,
Verlag Elsevier
Verlagsort New York, NY
Institut(e) Institute of Diabetes and Regeneration Research (IDR)