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Dystonia: Insights into mechanisms and Nnvel therapeutics.
Curr. Neurol. Neurosci. Rep. 26:8 (2026)
PURPOSE OF REVIEW: Dystonia is a highly heterogeneous movement disorder with complex molecular underpinnings. This review aims to synthesize insights into pathophysiological mechanisms driving dystonia with emphasis on latest advances. RECENT FINDINGS: In recent years, key molecular pathways in dystonia have been elucidated, among them: aberrant transcriptional regulation, altered protein turnover, nuclear envelope dysfunction, and mitochondrial impairment. Emerging data reveal the interplay and convergence of some of these disease-related processes, highlighting overarching molecular vulnerabilities critical to pathogenesis. Deciphering molecular mechanisms underlying dystonia facilitates the stratification of affected individuals into biologically defined subgroups, which will be essential for the development of targeted therapies. Patient assessment based on individual molecular profiles represents a promising avenue for future therapeutic and preventive strategies in dystonia.
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Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Review
Schlagwörter
Dystonia ; Genetics ; Molecular Pathways ; Pathogenesis ; Therapeutics; Atp Synthase; Neurodevelopmental Disorders; Nuclear-envelope; Coenzyme Q(10); Double-blind; Gene Dyt1; Thap1; Aminopeptidases; Mitochondria; Mutations
ISSN (print) / ISBN
1528-4042
e-ISSN
1534-6293
Zeitschrift
Current Neurology and Neuroscience Reports
Quellenangaben
Band: 26,
Heft: 1,
Artikelnummer: 8
Verlag
Springer
Verlagsort
One New York Plaza, Suite 4600, New York, Ny, United States
Begutachtungsstatus
Peer reviewed
Institut(e)
Institute of Neurogenomics (ING)
Förderungen
Technische Universitt Mnchen (1025)