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Division asymmetry drives cell size variability in budding yeast.
eLife 15:RP109269 (2026)
Cell size variability within proliferating populations reflects the
interdependent regulation of cell growth and division as well as
intrinsically stochastic effects. In budding yeast, the G1/S transition
exerts strong size control in daughter cells, which manifests as the
inverse correlation between how big a cell is when it is born and how
much it grows in G1. However, mutations affecting this size control
checkpoint only modestly influence population-wide size variability,
often altering the coefficient of variation (CV) only by ∼10%. To
resolve this paradox, we combine computational modeling and live-cell
imaging to identify the principal determinants of cell size variability.
Using an experimentally validated stochastic model of the yeast cell
cycle, we perform parameter sensitivity analysis and find that division
asymmetry between mothers and daughters is the dominant driver of CV,
outweighing the effects of G1/S size control. Experimental measurements
across genetic perturbations and growth conditions confirm a strong
correlation between mother-daughter size asymmetry and population CV.
These findings reconcile previous observations and show how asymmetric
division operates in concert with G1/S size control to govern cell size
heterogeneity.
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Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Wissenschaftlicher Artikel
ISSN (print) / ISBN
2050-084X
e-ISSN
2050-084X
Zeitschrift
eLife
Quellenangaben
Band: 15,
Artikelnummer: RP109269
Verlag
eLife Sciences Publications
Begutachtungsstatus
Peer reviewed
Institut(e)
Institute of Functional Epigenetics (IFE)