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Cingir Koker, S. ; Mhamane, A. ; Geppert, J. ; Shakir, G.* ; Guillamat-Prats, R.* ; Chen, B.* ; Katra, P.* ; Geiger, M.* ; Tsokanos, F.-F. ; Wolff, G. ; Szendrödi, J. ; Rohm, M. ; Daniel, C. ; Maegdefessel, L.* ; Steffens, S. ; Herzig, S.

Nuclear receptor co-factor TBL1X/TBL1XR1 T cell activity protects against atherosclerosis.

Mol. Metab. 104:102318 (2026)
Verlagsversion Forschungsdaten DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
Atherosclerosis is a long-term complication of obesity and diabetes and as such a key driver of vascular dysfunction and eventually mortality in affected patients. Both aberrant lipid metabolism and inflammatory reactions promote atherosclerotic plaque development in the vessel wall by triggering a cascade of cellular events involving multiple cell types, including smooth muscle cells, monocytic macrophages, and lymphocytes. Despite its eminent impact on human health, molecular drivers of cellular dysfunction in atherosclerosis remain poorly defined and therapeutic options are scarce. Here we show by single-cell RNA sequencing that the expression of the nuclear receptor co-factors, TBL1X and TBL1XR1, was particularly prominent in the CD4+ T cell population of human carotid artery plaques. Indeed, genetic double deletion of TBL1X/TBL1XR1 in CD4+ T cells led to a substantial shift from naïve CD44lowCD62Lhi cells to CD44hiCD62Llow effector and Foxp3+ Tregs. CD4+ TBL1X/TBL1XR1 KO cells exhibited enhanced cytokine production capacity upon ionomycin/PMA stimulation, correlating with the induction of pro-inflammatory and cytokine-producing transcriptional pathways in these cells. Consistently, transplantation of bone marrow from CD4+-specific TBL1X/TBL1XR1 knock out mice into LDLR KO recipients doubled the development of atherosclerotic plaques in the aortic arch compared with wild-type bone marrow transplanted littermates. As TBL1X/TBL1XR1 expression levels were diminished in carotid arteries from patients with advanced unstable plaques compared to stable plaques or healthy controls, these data suggest that aberrant inhibition of TBL1X/TBL1XR1 in CD4+ T cells may contribute to the development of atherosclerosis in humans. Restoration of TBL1X/TBL1XR1 functionality may thus serve as a novel, druggable strategy for preventing or limiting atherosclerosis progression.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Atherosclerosis ; Cd4⁺ T Cells ; Nuclear Receptor Coregulators ; Tbl1x/tbl1xr1; Tbl1; Repression
ISSN (print) / ISBN 2212-8778
e-ISSN 2212-8778
Zeitschrift Molecular Metabolism
Quellenangaben Band: 104, Heft: , Seiten: , Artikelnummer: 102318 Supplement: ,
Verlag Elsevier
Verlagsort Amsterdam
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Diabetes and Cancer (IDC)
Research Unit Type 1 Diabetes Immunology (TDI)
Förderungen German Centers for Health Research (DZG) innovation fund
German Center for Cardiovascular Research (DZHK) excellence grant
European Research Council (ERC)
German Ministry of Research and Education
The "Atherosclerosis" (Deutsche Forschungsgemeinschaft)