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Yang, L.* ; Ru, J. ; Guo, S.* ; Yang, X.* ; Li, P.* ; Deng, L. ; Wang, X.*

Research note: The chicken gut virome: Spatiotemporal dynamics and divergent responses to antibiotic versus phytogenic supplementation.

Poult. Sci. 105:106373 (2026)
Verlagsversion DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
This study employed metagenomic sequencing data to comprehensively investigate the gut virome, with a focus on the bacteriophage communities (the phageome), across intestinal regions and developmental stages in 360 chickens. We characterized the spatiotemporal dynamics of phage communities and assessed the impact of chlortetracycline (CTC), an antibiotic, and Macleaya cordata extract (MCE), a phytogenic supplement. Our analysis revealed that phage community assembly was highly structured, exhibiting distinct successional patterns across age and between foregut and hindgut segments. A key finding was the identification of a potential antibiotic-phage synergy, mediated by phage-encoded auxiliary metabolic genes (AMGs) involved in bacterial immune evasion, suggesting a novel mechanism for enhanced infectivity under antibiotic pressure. In contrast, phytogenic supplementation promoted gut ecosystem homeostasis by fostering significantly richer and more diverse phage communities. Our results delineate the fundamental ecology of the chicken gut virome and provide mechanistic insights into how different growth promoters exert contrasting effects on viral populations, supporting the use of phytogenics as sustainable alternatives for animal husbandry.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Antibiotic Alternative ; Feed Additives ; Gut Virome ; Phage-bacteria Interaction ; Phytogenics
ISSN (print) / ISBN 0032-5791
e-ISSN 1525-3171
Zeitschrift Poultry Science
Quellenangaben Band: 105, Heft: 3, Seiten: , Artikelnummer: 106373 Supplement: ,
Verlag Elsevier
Verlagsort Radarweg 29, 1043 Nx Amsterdam, Netherlands
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Virology (VIRO)
Förderungen European Research Council Starting grant (ERC)
Deutsche Forschungsgemeinschaft (DFG)
China Agriculture Research System of MOF and MARA
National Key R & D Program of China