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Jäger, E.* ; Peeva, V.* ; Gnad, T.* ; Haange, S.B.* ; Rolle-Kampczyk, U.* ; Stäubert, C.* ; Krumbholz, P.* ; Heiker, J.T. ; Gebhardt, C. ; Krügel, U.* ; Sen, P.* ; Harazin, M.* ; Stab, V.* ; Münzker, J.* ; Hamdani, N.* ; Pfeifer, A.* ; von Bergen, M.* ; Till, A.* ; Fenske, W.K.*

Antibiotic-mediated modulation of the gut microbiome identifies taurine as a modulator of adipocyte function through TGR5 signaling.

Int. J. Mol. Sci. 27:917 (2026)
Verlagsversion Forschungsdaten DOI PMC
Open Access Hybrid
Creative Commons Lizenzvertrag
Gut microbiota has emerged as a modulator of host metabolism and energy balance. However, the precise microbial metabolites mediating thermogenic activation in obesity remain largely undefined. We investigated the effect of antibiotic treatment under a high-fat diet on metabolites and its contribution to lipolysis and thermogenesis. Antibiotic treatment in high-fat diet-fed rats reduced adiposity and enhanced adaptive thermogenesis. Metabolomics revealed elevated taurine levels in the cecum content and plasma of antibiotic-treated animals, correlating with increased expressions of UCP1 and TGR5 in brown adipose tissue. Taurine enhanced lipolysis and oxygen consumption in mouse adipose tissue and human adipocytes. Thereby, taurine modulated lipolysis dependent on TGR5 signaling in adipose tissue. Human data confirmed that taurine promotes browning of white adipocytes and that acute cold exposure leads to a marked drop in circulating taurine, suggesting its rapid recruitment into thermogenic tissues. Besides its synthesis in the liver and dietary uptake, taurine can be a microbiota-derived metabolite that activates adipose thermogenesis and lipolysis through TGR5 and possibly taurine transporter-dependent mechanisms. These findings uncover a gut-adipose axis with therapeutic potential for metabolic disease.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Taurine ; Lipolysis ; Adipocyte ; Thermogenesis ; White Adipose Tissue ; Adipose Tissue ; Brown Adipose Tissue ; Metabolomics; Brown Adipose-tissue; Obesity; Supplementation; Disease; Acids; Diet
ISSN (print) / ISBN 1661-6596
e-ISSN 1422-0067
Zeitschrift International Journal of Molecular Sciences
Quellenangaben Band: 27, Heft: 2, Seiten: , Artikelnummer: 917 Supplement: ,
Verlag MDPI
Verlagsort Basel
Begutachtungsstatus Peer reviewed
Institut(e) Helmholtz Institute for Metabolism, Obesity and Vascular Research (HI-MAG)
Förderungen DFG
BMBF