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Associations of physical activity and sedentary behaviors with mortality: An observational analysis and Mendelian randomization study.
Geriatr. Nurs. 68:103834 (2026)
BACKGROUND: To investigate the associations of physical activity (PA) and sedentary behavior (SB) with the risk of mortality using observational and Mendelian randomization (MR) designs. METHODS: In a prospective cohort study based on UK Biobank, data on PA and SB were collected and categorized as three mutually exclusive groups. Multivariable-adjusted Cox models and two-sample MR analysis were performed. RESULTS: Compared with low total PA (TPA), intermediate and high TPA were associated with a decreased risk of all-cause and cardiovascular disease (CVD) mortality. Compared with low levels, high total sitting time and television viewing time were associated with increased risk of all-cause and CVD mortality. The two-sample MR analysis indicated no causal relationship between genetic predispositions to PA/SB and mortality. CONCLUSIONS: Although PA was associated with a lower risk, prolonged sitting time was associated with an increased risk of all-cause and CVD mortality, two-sample MR did not support a causal effect.
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Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Wissenschaftlicher Artikel
Schlagwörter
Epidemiology ; Mendelian Randomization ; Mortality ; Physical Activity ; Sedentary Behavior; Adults; Time; Inactivity; Disease; Risk
ISSN (print) / ISBN
0197-4572
e-ISSN
1528-3984
Zeitschrift
Geriatric Nursing
Quellenangaben
Band: 68,
Artikelnummer: 103834
Verlag
Elsevier
Verlagsort
360 Park Avenue South, New York, Ny 10010-1710 Usa
Begutachtungsstatus
Peer reviewed
Institut(e)
Institute of Translational Genomics (ITG)