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Li, H.* ; Yan, W.* ; Liu, X.* ; Gao, B.* ; Peng, J.* ; Jiang, F.* ; Cui, Q.* ; Song, C.* ; Kong, X.* ; Li, H.* ; Stöger, T. ; Wajid, A.* ; Dodovski, A.* ; Gao, C.* ; Lusida, M.I.* ; Mingala, C.N.* ; Andreychuk, D.B.* ; Yin, R.*

Emergence and phylodynamics of influenza D virus in Northeast China reveal sporadic detection and predominance of the D/Yamagata/2019 lineage in Cattle.

Viruses 18:93 (2026)
Verlagsversion DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
Influenza D virus (IDV), an emerging orthomyxovirus with zoonotic potential, infects diverse hosts, causes respiratory disease, and remains poorly characterized in China despite its global expansion. From October 2023 to January 2025, we collected 563 nasal swabs from cattle across 28 farms in Jilin Province, Northeast China, and identified seven IDV-positive samples (1.2%), recovering two viable isolates (JL/YB2024 and JL/CC2024). Full-genome sequencing revealed complete, stable seven-segment genomes with high nucleotide identity (up to 99.9%) to contemporary Chinese D/Yamagata/2019 strains and no evidence of reassortment. Maximum-likelihood and time-resolved Bayesian phylogenies of 231 global hemagglutinin-esterase-fusion (HEF) sequences placed the Jilin isolates within the East Asian D/Yamagata/2019 clade and traced their most recent common ancestor to approximately 2017 (95% highest posterior density: 2016-2018), suggesting a cross-border introduction likely associated with regional cattle movement. No IDV was detected in parallel surveillance of swine, underscoring cattle as the principal reservoir and amplifying host. Bayesian skyline analysis demonstrated a marked decline in global IDV genetic diversity during 2020-2022, coinciding with livestock-movement restrictions imposed during the COVID-19 pandemic. Collectively, these findings indicate that IDV circulation in China is sporadic and geographically localized, dominated by the D/Yamagata/2019 lineage, and shaped by multiple independent incursions rather than a single emergence. Both the incorporation of IDV diagnostics into routine bovine respiratory disease surveillance and cattle-import quarantine programs, and the adoption of a One Health framework to monitor potential human spillover and future viral evolution, were recommend.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter China ; D/yamagata/2019 Lineage ; Cattle Reservoir ; Influenza D Virus ; Phylogeography; Phylogenetic Lineage; Transmission; Exposure
ISSN (print) / ISBN 1999-4915
e-ISSN 1999-4915
Zeitschrift Viruses
Quellenangaben Band: 18, Heft: 1, Seiten: , Artikelnummer: 93 Supplement: ,
Verlag MDPI
Verlagsort Mdpi Ag, Grosspeteranlage 5, Ch-4052 Basel, Switzerland
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Lung Health and Immunity (LHI)
Förderungen Natural Science Foundation of Jilin Province
Macedonian- Chinese Scientific and Technological Cooperation project
Shanxi Province Science and Technology Cooperation and Exchange Project