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Purifying selection on deleterious variants affected by the combination of subgenomes and gene expression in bread wheat.
Cell Rep. 45:116785 (2026)
Verlagsversion
Forschungsdaten
DOI
PMC
The genome-wide pattern of purifying selection on deleterious variants has attracted broad interest in breeding and evolutionary biology. Little is known about purifying selection in polyploid species with potential functional redundancy of duplicated homoeologs. Here, we examine the pattern of polymorphisms and the combined effects of both subgenome and gene expression on estimates of purifying selection in the allohexaploid bread wheat. We utilize the de novo annotated assemblies and transcriptome data of the 10+ Wheat Genome Project. Purifying selection is detected after filtering chromosomes harboring segregating foreign introgression by modern breeding. Interestingly, strong purifying selection is observed in the category of genes that are highly expressed in root tissues and are in the D subgenome, which is thought to contribute to the range expansion after allopolyploidization. We suggest that the combination of expressed tissues and subgenomes will inform the target of future wheat breeding to mitigate the effect of deleterious variants.
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Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Wissenschaftlicher Artikel
Schlagwörter
Cp: Genomics ; Cp: Plants ; Allohexaploid ; Evolution ; Genome ; Purifying Selection ; Subgenome ; Transcriptome ; Wheat; Effect Size; Adaptive Evolution; Plant; Highlights; Diversity; Patterns; Improvement; Statistics; Annotation; Mutations
ISSN (print) / ISBN
2211-1247
e-ISSN
2211-1247
Zeitschrift
Cell Reports
Quellenangaben
Band: 45,
Heft: 2,
Artikelnummer: 116785
Verlag
Elsevier
Verlagsort
50 Hampshire St, Floor 5, Cambridge, Ma 02139 Usa
Begutachtungsstatus
Peer reviewed
Förderungen
Manitoba Crop Alliance
JSPS KAKENHI
Core Research for Evolutionary Science and Technology
FOREST Program
Japan Science and Technology Agency
University Research Priority Program in Evolution in Action of the University of Zurich
CTAG2 project - Genome Canada
Saskatchewan Ministry of Agriculture, Western Grains Research Foundation
Saskatchewan Wheat Development Commission
Swiss National Science Foundation
JSPS KAKENHI
Core Research for Evolutionary Science and Technology
FOREST Program
Japan Science and Technology Agency
University Research Priority Program in Evolution in Action of the University of Zurich
CTAG2 project - Genome Canada
Saskatchewan Ministry of Agriculture, Western Grains Research Foundation
Saskatchewan Wheat Development Commission
Swiss National Science Foundation