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Kamiza, A.B.* ; Chikowore, T.* ; Chen, G.* ; Ojewunmi, O.* ; Machipisa, T.* ; Zhou, F.* ; Mayanja, R.* ; Toure, S.* ; Soremekun, O. ; Kintu, C.* ; Nakabuye, M.* ; Koprulu, M.* ; Kalungi, A.* ; Kalyesubula, R.* ; Salako, B.* ; Nashiru, O.* ; Corpas, M.* ; Robinson-Cohen, C.* ; Franceschini, N.* ; Pattaro, C.* ; Köttgen, A.* ; Nitsch, D.* ; Langenberg, C.* ; Tcheandjieu, C.* ; Nyirenda, M.* ; Morris, A.P.* ; Asimit, J.* ; Zeggini, E. ; Rotimi, C.* ; Ramsay, M.* ; Adeyemo, A.* ; Fabian, J.* ; Crampin, A.C.* ; Brandenburg, J.T.* ; Fatumo, S.*

KidneyGenAfrica multi-cohort Genome-wide association study and polygenic prediction of kidney function in 110,000 Africans.

Nat. Commun. 17:2599 (2026)
Verlagsversion DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
Kidney disease disproportionately affects populations of African ancestry, yet most genetic studies have focused on Europeans. Here, we present a three-stage genome-wide association study meta-analysis of estimated glomerular filtration rate in ~26,000 individuals across Eastern, Western, and Southern Africa and ~81,000 African-ancestry individuals in the diaspora. Continental African meta-analysis identifies four independent genome-wide significant loci, including two previously unreported loci. Pan-African meta-analysis identifies 19 independent loci, including three previously unreported loci. Fine-mapping reveals four loci with high causality probability, and phenome-wide analyses demonstrate pleiotropic effects on cardiometabolic and immunological traits. Notably, APOL1 high-risk variants strongly associated with kidney disease in African Americans show markedly lower frequency and attenuated effects in continental Africa, indicating potential distinct genetic architectures. Polygenic scores from genetically similar populations significantly outperformed those from distant cohorts. These findings demonstrate the necessity of conducting genomic research across diverse African populations to enable equitable health outcomes.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Genome-wide Association Study ; Kidney Disease ; Genetic Association ; Disease ; Renal Function ; Causality (physics) ; Genetic Variation ; Genetic Variants; Disease; Populations; Insights; Metaanalysis; Discovery; Variants; Origins; History; Decline; Biobank
ISSN (print) / ISBN 2041-1723
e-ISSN 2041-1723
Zeitschrift Nature Communications
Quellenangaben Band: 17, Heft: 1, Seiten: , Artikelnummer: 2599 Supplement: ,
Verlag Springer
Verlagsort London
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Translational Genomics (ITG)
Förderungen Wellcome Trust (Wellcome)
RCUK | Medical Research Council (MRC)