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Benchmarking in vivo and in vitro gene co-expression networks enables efficient β-like cell differentiation.
Dev. Cell 61, 229-231 (2026)
In this issue of Developmental Cell, Yu et al.1 reconstruct human embryonic gene co-expression networks (GCNs) that guide pancreatic endocrine lineage specification. Benchmarking stem cell-derived islet (SC-islet) differentiation protocols against fetal human pancreatic cells reveals early regulatory divergences, thereby enabling the design of a protocol with improved β-like cell production.
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Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Editorial
ISSN (print) / ISBN
1534-5807
e-ISSN
1878-1551
Zeitschrift
Developmental Cell
Quellenangaben
Band: 61,
Heft: 2,
Seiten: 229-231
Verlag
Elsevier
Verlagsort
50 Hampshire St, Floor 5, Cambridge, Ma 02139 Usa
Begutachtungsstatus
Peer reviewed
Institut(e)
Institute of Pancreatic Islet Research (IPI)