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Heider, S.* ; Gohlke, S.* ; Kuxhaus, O.* ; Haueise, T. ; Stefan, N. ; Birkenfeld, A.L. ; Machann, J. ; Schulz, T.J.*

Bone marrow adipose tissue mass and dipeptidyl peptidase-4 link aging and metabolic health to biomarkers of bone turnover.

Am. J. Physiol. Endocrinol. Metab. 330, E411-E421 (2026)
Verlagsversion DOI PMC
Open Access Hybrid
Creative Commons Lizenzvertrag
Bone marrow adipose tissue (BMAT) has been linked to negative bone health outcomes and a high level of bone marrow adipocyte accumulation is observed during aging and in individuals with diabetes and obesity. This study explores the relationships between BMAT, age, metabolic health and the impact of their interactions on bone turnover in a cross-sectional cohort of healthy women and men. Levels of bone turnover biomarkers, procollagen type 1 N-terminal propeptide (P1NP) and beta-Crosslaps (CTX) were determined alongside dipeptidyl peptidase-4 (DPP4) concentration and activity as biomarkers of metabolic health. We used magnetic resonance imaging to assess proton density fat fraction (PDFF) to quantify BMAT mass in heathy individuals, and correlated results to sex, age, body mass index (BMI) and glycated hemoglobin A1c (HbA1c), which represents long-term glycemic control. Age was the strongest determinant of increased BMAT mass, explaining more than a third of its overall variation, as well as a robust determinant of bone turnover. A sex-specific correlation pattern was observed between BMAT and bone turnover: Women displayed a trend for a positive correlation of BMAT which depended on age. In men, BMAT mass correlated significantly, but inversely, with both biomarkers, which was also age-dependent. Dipeptidyl peptidase-4 concentration and activity were positively associated with P1NP in both sexes and these relationships were independent of age, BMI or HbA1c. These findings indicate that the impact of BMAT on bone turnover may be age-dependent, whereas metabolic regulator DPP4 is linked to bone turnover independently of metabolic health or aging.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Bone Marrow Adipose Tissue (bmat) ; Dipeptidyl Peptidase-4 ; Aging ; Bone Turnover ; Metabolic Health
ISSN (print) / ISBN 0193-1849
e-ISSN 1522-1555
Zeitschrift American Journal of Physiology - Endocrinology and Metabolism
Quellenangaben Band: 330, Heft: 4, Seiten: E411-E421 Artikelnummer: , Supplement: ,
Verlag American Physiological Society
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Diabetes Research and Metabolic Diseases (IDM)