Startseite
English
Erweiterte Suche
Durchblättern nach ...
Publikationen im Überblick
Ansprechpartner
Hilfe
DOI
PMC
 |
|
möglich sobald bei der ZB eingereicht worden ist.
Muscle-immune metabolic crosstalk: Shared pathways in cachexia and exercise.
Curr. Opin. Biotechnol. 98:103455 (2026)
Skeletal muscle and the immune system continuously exchange metabolites and signals that are essential for homeostasis. Disruption of this communication, such as during infection, inflammation, or cancer, triggers cachexia, a severe wasting syndrome characterized by altered amino acid flux, mitochondrial dysfunction, and systemic energy imbalance. By contrast, regular exercise activates overlapping pathways but directs them toward regeneration and hypertrophy, supported by controlled cytokine release and metabolite exchange. This review outlines the metabolic reprogramming that underlies muscle-immune crosstalk in cachexia and exercise, emphasizing how identical mediators, including interleukin-6, can promote either catabolism or adaptation depending on context. Understanding these shared yet divergent pathways opens avenues for therapeutic strategies that target metabolism and immune-metabolic communication.
Altmetric
Weitere Metriken?
Zusatzinfos bearbeiten
[➜Einloggen]
Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Review
Schlagwörter
Skeletal-muscle; Protein-synthesis; Amino-acids; Il-6; Macrophages; Regeneration; Inhibition; Catabolism; Expression; Responses
ISSN (print) / ISBN
0958-1669
e-ISSN
1879-0429
Zeitschrift
Current Opinion in Biotechnology
Quellenangaben
Band: 98,
Artikelnummer: 103455
Verlag
Elsevier
Verlagsort
Amsterdam
Begutachtungsstatus
Peer reviewed
Institut(e)
Institute of Diabetes and Cancer (IDC)
Förderungen
Deutsche Forschungsgemeinschaft (DFG) , Germany
German Centers for Health Research (DZG) , Germany, Innovation Fund
Novo Nordisk Foundation, Denmark, through the European Foundation for the Study of Diabetes (EFSD)/Novo Nordisk Foundation Future Leaders Award
German Center for Diabetes Research (DZD) , Germany, Next Grant
Helmholtz Association, Germany, Initiative and Networking Fund
European Research Council (ERC) , European Union
German Centers for Health Research (DZG) , Germany, Innovation Fund
Novo Nordisk Foundation, Denmark, through the European Foundation for the Study of Diabetes (EFSD)/Novo Nordisk Foundation Future Leaders Award
German Center for Diabetes Research (DZD) , Germany, Next Grant
Helmholtz Association, Germany, Initiative and Networking Fund
European Research Council (ERC) , European Union