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Dragunas, G. ; Klotz, M. ; Chen, S. ; Ertüz, Z. ; Tan, X. ; Korkmaz, R.Ü. ; Shankhwar, S. ; Rankl, B. ; Dhakad, D. ; Omony, J. ; Mayr, C.H. ; Chen, Y. ; Agami, A. ; Lin, C.-W. ; Müller, C.* ; Lunding, L.* ; Wegmann, M.* ; Berner, J.* ; Popovic, J.* ; Schraml, B.U.* ; Adler, H. ; Falter-Braun, P. ; Schiller, H.B. ; Watz, H.* ; Conlon, T.M. ; Jeridi, A. ; Kapellos, T. ; von Mutius, E. ; Yildirim, A.Ö.

A beneficial environment promotes immune resilience through epigenetic regulation.

Sci. Adv. 12:eady7317 (2026)
Verlagsversion Forschungsdaten DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
Environmental factors are often detrimental; however, certain environments enhance immune resilience. Notably, children raised on traditional farms show reduced allergies and asthma prevalence. Here, we investigated how a beneficial environment, using farm dust (FD) extract, influenced lung immune function in ovalbumin-induced allergic inflammation. FD exposure reduced allergic lung inflammation and increased monocyte-derived macrophage (MDM) recruitment. Single-cell RNA sequencing revealed that FD-exposed MDMs had altered gene expression, including dampened Ccl8 and major histocompatibility complex class II expression, impairing eosinophil recruitment and antigen presentation. RNA sequencing and assay for transposase-accessible chromatin using sequencing confirmed FD-induced epigenetic reprogramming ex vivo, on bone marrow-derived macrophages. This modulation, seen in both human and murine cells, relied on histone deacetylase activity sustained by peroxisome proliferator-activated receptor γ signaling. These findings suggest that beneficial environmental exposures can reprogram immune cells and may offer a previously unidentified strategy for asthma prevention.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Epigenetics ; Immune System ; Chromatin ; Major Histocompatibility Complex ; Reprogramming ; Allergy ; Inflammation ; Allergic Inflammation ; Antigen Presentation ; Innate Immune System; Class-ii; Ppar-gamma; Expression; Macrophage; Asthma; Roles; Transrepression; Transactivator; Inflammation; Activation
ISSN (print) / ISBN 2375-2548
e-ISSN 2375-2548
Zeitschrift Science Advances
Quellenangaben Band: 12, Heft: 9, Seiten: , Artikelnummer: eady7317 Supplement: ,
Verlag American Association for the Advancement of Science (AAAS)
Verlagsort Washington, DC [u.a.]
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Lung Health and Immunity (LHI)
Institute of Asthma and Allergy Prevention (IAP)
Research Unit Precision Regenerative Medicine (PRM)
Institute of Network Biology (INET)
Förderungen Innovation Programme
European Union's Horizon 2020 Research
ERC Starting Grant
ERC Advanced Grant
German Center for Lung Research (DZL)