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Hankofer, V. ; Ghirardo, A. ; Obermaier, L.* ; Poschet, G.* ; Kumar, J.S. ; Gross, I. ; Durner, J. ; Rychlik, M.* ; Wirtz, M.* ; Hell, R.* ; Schnitzler, J.-P. ; Groth, M.

Photorespiration is linked to DNA methylation by formate as a one-carbon source.

Nat. Plants 12, 653-664 (2026)
Verlagsversion Forschungsdaten DOI PMC
Open Access Hybrid
Creative Commons Lizenzvertrag
Photorespiration is a costly cellular process that reduces photosynthetic efficiency. While mitigating photorespiratory losses could boost crop yields, the interconnection of photorespiration with other processes is increasingly recognized. Its high carbon turnover generates mitochondrial one-carbon (C1) metabolites, including formate, but their contribution to cellular C1 metabolism has remained unclear. DNA methylation is an important epigenetic modification that depends on methyl groups provided by folate-mediated C1 metabolism. Here we show that photorespiration supplies C1 units for DNA methylation in Arabidopsis. We demonstrate that carbon from formate is incorporated into 5-methylcytosine through the C1-tetrahydrofolate synthase pathway, which operates predominantly during the day. Elevated CO2 that suppresses photorespiration alters the methylome, especially when the serine-derived C1 supply, which compensates for a blocked formate-derived supply, is compromised. These findings establish a metabolic link between photorespiration and epigenome stability and provide a framework for understanding methylome dynamics under rising CO2 levels and other environmental influences on photorespiration.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Glycine Decarboxylase Complex; Serine Hydroxymethyltransferase; Plant-cells; Arabidopsis; Metabolism; 5,10-methenyltetrahydrofolate; 5-formyltetrahydrofolate; Dehydrogenase; Biosynthesis; Expression
ISSN (print) / ISBN 2055-026X
e-ISSN 2055-0278
Zeitschrift Nature Plants
Quellenangaben Band: 12, Heft: 3, Seiten: 653-664 Artikelnummer: , Supplement: ,
Verlag Nature Publishing Group
Verlagsort London
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Biochemical Plant Pathology (BIOP)
Research Unit Environmental Simulation (EUS)
Förderungen H2020-MSCA individual fellowship 798235
EC | EU Framework Programme for Research and Innovation H2020 | H2020 Priority Excellent Science | H2020 Marie Sklodowska-Curie Actions (H2020 Excellent Science - Marie Sklodowska-Curie Actions)
Deutsche Forschungsgemeinschaft (German Research Foundation)