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Möser, C.* ; Prystupa, K.* ; Schön, M.* ; Yurchenko, I.* ; Bódis, K.B.* ; Huttasch, M.* ; Michelotti, F.* ; Kupriyanova, Y.* ; Schrauwen-Hinderling, V.* ; Granata, C.* ; Bönhof, G.J.* ; Strom, A.* ; Herder, C.* ; Dörr, D.* ; Trenkamp, S.* ; Heilmann, G.* ; Bobrov, P.* ; Straßburger, K.* ; Szendroedi, J. ; Cramer, M.* ; Polzin, A.* ; Jung, C.* ; Kelm, M.* ; Burkart, V.* ; Wagner, R.* ; Roden, M.* ; Zaharia, O.P.*

Cohort profile: The DIabetes and ST-segment Elevation Myocardial Infarction (DISTEMI) Study.

Cardiovasc. Diabetol. 25:96 (2026)
Verlagsversion DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
BACKGROUND: Humans with type 2 diabetes and/or metabolic dysfunction-associated steatotic liver disease (MASLD) are at higher risk of ST-segment elevation myocardial infarction (STEMI) and worse prognosis. However, mechanisms, prognostic factors and risk subtypes in humans with STEMI and (pre)diabetes with or without MASLD, are not fully understood. METHODS: The DIabetes and ST-segment Elevation Myocardial Infarction (DISTEMI) study is a prospective longitudinal cohort study, recruiting humans with different degrees of glucose tolerance after recent STEMI. This cohort study has the primary objective to detect changes in glycemia and insulin sensitivity derived from the oral glucose tolerance test (OGTT) and their relationships to cardiac function. Secondary objectives address tissue-specific insulin sensitivity and organ function, focusing on adipose tissue, liver and heart. Exploratory objectives comprise multiomic analyses and measures of mitochondrial function and quality of life. At 2 and 12 months after STEMI, participants undergo comprehensive cardiometabolic phenotyping (OGTT, modified Botnia clamp-test, magnetic resonance imaging/spectroscopy/elastography, high-resolution respirometry). Magnetic resonance-based techniques are employed to assess cardiovascular function and structure, adipose tissue distribution, skeletal muscle and hepatic lipid deposition and fibrosis, and hepatic energy metabolism. Exploratory analyses include multiomics of blood, urine, and stool samples. Multiomics analyses shall allow detecting biomarkers for stratification of cardiovascular disease risk. Currently, 100 participants have been included in DISTEMI, of whom 29% have type 2 diabetes. CONCLUSION: The DISTEMI study integrates comprehensive cardiometabolic phenomic with multiomic profiling to identify cardiometabolic STEMI subtypes and predictors of outcomes, and to improve precision risk stratification and targeted prevention. TRIAL REGISTRATION: NCT05046483.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Cardiovascular Function ; Cohort Profile ; Diabetes Mellitus ; Energy Metabolism ; Glucose Tolerance ; Insulin Sensitivity ; Magnetic Resonance Imaging ; Magnetic Resonance Spectroscopy ; Myocardial Infarction ; Steatotic Liver Disease; Magnetic-resonance-spectroscopy; Induced Insulin-resistance; Fatty Liver-disease; Risk-factors; Cardiovascular-disease; Mortality; Outcomes; Type-1; Reproducibility; Elastography
ISSN (print) / ISBN 1475-2840
e-ISSN 1475-2840
Zeitschrift Cardiovascular Diabetology
Quellenangaben Band: 25, Heft: 1, Seiten: , Artikelnummer: 96 Supplement: ,
Verlag Springer
Verlagsort Campus, 4 Crinan St, London N1 9xw, England
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Diabetes and Cancer (IDC)
Förderungen Universittsklinikum Dsseldorf. Anstalt ffentlichen Rechts (8911)