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Hermant, C. ; Mourra-Díaz, D.M. ; Oomen, M.E. ; Jansz, N. ; Noll, C. ; Canat, A. ; Pal, M. ; Nakatani, T. ; Schauer, T. ; Torres-Padilla, M.E.

TBP regulates transposable element expression in early mouse embryos.

EMBO J. 45, 3073–3101 (2026)
Verlagsversion Forschungsdaten DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
The activation of the embryonic genome is a crucial step in development. In addition to thousands of genes, many transposable elements (TEs) are robustly transcribed during early mammalian development. However, their transcriptional regulators remain largely unexplored. Here, we set out to identify transcription factors regulating the expression of TEs from the LINE, SINE and ERVL families during mouse preimplantation development. In particular, the MaLR family are the most abundant ERVL in the mouse genome and are also the most abundant constituent of the transcriptome in early mouse embryos. We find that the general transcription factor TBP binds and activates MaLRs in mouse embryos. Loss-of-function of TBP leads to downregulation of MaLRs, specifically the ORR1A family, which is the youngest ORR subclass and contributes a significant portion of major zygotic genome activation transcripts. Our work identifies regulators of TE expression in vivo and highlights a previously unrecognised role for the general transcription factor TBP in regulating a highly specific TE transcriptional programme.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Ervl ; Malr ; Mouse Embryos ; Retrotransposons ; Tbp; Rna-polymerase-ii; Gene-expression; Transcription Initiation; Mediated Activation; Crystal-structure; Ctcf-binding; Chromatin; Cells; Seq; Promoter
ISSN (print) / ISBN 0261-4189
e-ISSN 1460-2075
Zeitschrift EMBO Journal, The
Quellenangaben Band: 45, Heft: , Seiten: 3073–3101 Artikelnummer: , Supplement: ,
Verlag Springer
Verlagsort Heidelberg, Germany
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Epigenetics and Stem Cells (IES)
Förderungen Helmholtz Association ((sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic))
Deutsche Forschungsgemeinschaft (DFG)