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Adhesion G protein-coupled receptors.

Pharmacol. Rev. 78:100116 (2026)
Verlagsversion DOI PMC
Open Access Hybrid
Creative Commons Lizenzvertrag
Adhesion G protein-coupled receptors (aGPCRs) constitute a structurally and functionally distinct group within the superfamily of GPCRs. In 2015, the International Union of Pharmacology invited the Adhesion GPCR Consortium to publish a comprehensive review about aGPCRs and establish a unified nomenclature. Since then, substantial progress has been made in delineating the biological roles, molecular architecture, biochemical properties, expression profiles, ligand repertoire, and activation and signaling strategies of aGPCRs. Commensurate with these advances, their relevance to human pathophysiology has become increasingly apparent. In a coordinated effort, the Adhesion GPCR Consortium has reviewed recent progress in this field and provides a comprehensive assessment of the current understanding of aGPCR biology, including a focus on human and mammalian aGPCRs, their evolutionary origins, methodological approaches, and model systems for their investigation, as well as emerging approaches for their therapeutic targeting. SIGNIFICANCE STATEMENT: Adhesion G protein-coupled receptors are versatile cell-surface proteins that integrate structural, biochemical, and physiological functions, with major roles in health and disease. This review summarizes current knowledge of their molecular features, functions in diverse model systems, and emerging opportunities for therapeutic targeting, providing a comprehensive resource that connects basic biology with translational applications across multiple scientific disciplines.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Review
Schlagwörter Planar Cell Polarity; Brain-specific Angiogenesis; 7-pass Transmembrane Cadherin; Bilateral Frontoparietal Polymicrogyria; Calcium-independent Receptor; Exome Sequencing Reveals; Promotes Myoblast Fusion; Genome-wide Association; Tumor-suppressor Gene; Alpha-latrotoxin
ISSN (print) / ISBN 0031-6997
e-ISSN 1521-0081
Zeitschrift Pharmacological reviews
Quellenangaben Band: 78, Heft: 3, Seiten: , Artikelnummer: 100116 Supplement: ,
Verlag Elsevier
Verlagsort Bethesda, Md.
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Diabetes and Cancer (IDC)
Förderungen CRC
National Institutes of Health
Deutsche Forschungsgesellschaft (DFG)
Secretaria de Educaci.on
Mitacs accelerate program
National Research Foundation (NRF) Singapore
German Academic Exchange Service (DAAD)
Alfred Sloan Foundation
Foundation Fighting Blindness
Independent Research Fund Denmark
National Science and Technology Council (NSTC), Taiwan
Cancer Research UK
Deutsche Herzstiftung e.V.
FRFS-WELBIO
NWO
Federal Ministry of Research, Technology and Space
Van Meir
National Institute of Mental Health (NIMH)
Wellcome Trust
Novo Nordisk Foundation
European Research Council (ERC)
Manfred Roth Stiftung