PuSH - Publikationsserver des Helmholtz Zentrums München

Chronopoulos, J.* ; Hajishengallis, G.* ; Chavakis, T.

Bone marrow rewired: Trained immunity and clonal hematopoiesis in metabolic disease.

Metabolism 180:156603 (2026)
Verlagsversion DOI PMC
Open Access Hybrid
Creative Commons Lizenzvertrag
Diseases associated with obesity and metabolic dysregulation, such as diabetes and metabolic dysfunction-associated steatotic liver disease (MASLD) promote chronic low-grade inflammation, which in turn, may enhance the risk for cardiovascular disease. Emerging evidence in recent years suggests that chronicity of inflammation involves alterations in bone marrow homeostasis. Obesity-related inflammation and metabolic stress, including hyperglycemia or hyperlipidemia, may trigger rewiring of hematopoietic stem and progenitor cells (HSPCs) in the bone marrow, driving production of myeloid cells with heightened inflammatory capacity that in turn fuel and sustain chronic inflammation. This process is akin to trained immunity and may promote an inflammatory memory that links metabolic disorders to their cardiovascular complications. Clonal hematopoiesis of indeterminate potential (CHIP) is characterized by aging-related emergence of somatic mutations in hematopoietic cells that clonally expand and bear higher inflammatory potential. Importantly, a bidirectional link between CHIP and metabolic disorders as well as their cardiovascular sequelae emerges. Here, we review current concepts regarding the links between bone marrow biology and metabolic diseases and associated chronic inflammation.
Altmetric
Weitere Metriken?
[➜Einloggen]
Zusatzinfos bearbeiten [➜Einloggen]
Publikationstyp Artikel: Journalartikel
Dokumenttyp Review
Schlagwörter Bone Marrow ; Clonal Hematopoiesis ; Diabetes ; Masld ; Obesity ; Trained Immunity; Adipose-tissue; Progenitor Cells; Stem-cells; Promotes Myelopoiesis; Epigenetic Changes; Obesity; Atherosclerosis; Inflammation; Impairs; Leukemia
ISSN (print) / ISBN 0026-0495
e-ISSN 1532-8600
Zeitschrift Metabolism: clinical and experimental
Quellenangaben Band: 180, Heft: , Seiten: , Artikelnummer: 156603 Supplement: ,
Verlag Elsevier
Verlagsort 1600 John F Kennedy Boulevard, Ste 1800, Philadelphia, Pa 19103-2899 Usa
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Pancreatic Islet Research (IPI)
Förderungen NIH/NIDCR
European Union
Deutsche Forschungsgemeinschaft