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Meier, C.Z.* ; Wagner, R. ; Ganslmeier, M. ; Kantartzis, K. ; Heni, M.* ; Peter, A. ; Jumpertz von Schwartzenberg, R. ; Machann, J. ; Schick, F. ; Birkenfeld, A.L. ; Häring, H.U.* ; Fritsche, A. ; Stefan, N.

Different metabolic responses to long-term weight loss after lifestyle intervention among type 2 diabetes risk clusters: Results from the TULIP Study.

Diabetes, DOI: 10.2337/db25-0757 (2026)
Postprint DOI PMC
Open Access Green
There may be heterogeneity in the response to a lifestyle intervention to prevent type 2 diabetes. This study investigated whether participants of Tübingen Lifestyle Intervention Program (TULIP) type 2 diabetes risk clusters 3 and 5, who have a very high risk of diabetes, benefit from long-term weight loss following a 2-year lifestyle intervention. Diabetes risk cluster 5 participants had an impaired response regarding improvement of glycemia and insulin secretion and a high risk of developing type 2 diabetes, despite a long-term (9-year) mean weight loss of 8%. Alternative or intensified interventions should be considered for people in Tübingen type 2 diabetes risk cluster 5.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
ISSN (print) / ISBN 0012-1797
e-ISSN 1939-327X
Zeitschrift Diabetes
Verlag American Diabetes Association
Verlagsort Alexandria, VA.
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Diabetes Research and Metabolic Diseases (IDM)
Förderungen German Centre for Diabetes Research (DZD)
German Federal Ministry of Education and Research (BMBF)