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Leuschner, G.* ; Prasse, A.* ; Klotsche, J.* ; Kreuter, M.* ; Wirtz, H.* ; Pittrow, D.* ; Frankenberger, M. ; Behr, J.*

Sex differences in IPF: Data from the German INSIGHTS Registry.

Respiration, DOI: 10.1159/000550309 (2026)
DOI
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Background: Idiopathic pulmonary fibrosis (IPF) preferentially occurs in male patients and controversial results in gender-specific differences including overall mortality have been reported. Methods: The INSIGHTS-IPF registry was a non-interventional, prospective cohort study including IPF patients from 20 interstitial lung disease expert centers in Germany. Sex-related disparities were analyzed regarding comorbidities, clinical course, and survival. Results: Of the 1,043 IPF patients included, 842 (80.7%) were male and 201 (19.3%) were female. Male patients were more likely to have a history of smoking (p < 0.001) and environmental exposure, especially metal dust, wood dust, and solvents (p = 0.032). While males at baseline had a higher prevalence of coronary artery disease, atrial fibrillation, emphysema, and obstructive sleep apnea syndrome, in females, gastro-esophageal reflux disease and depression or depressive disorders were more frequent. Female IPF patients had more frequently a history of immunosuppressive therapy (p = 0.003). Regardless of gender, the INSIGHTS-IPF cohort as a whole showed a progressive worsening of lung function parameters over time. All-cause mortality did not differ between females and males (HR: 0.81; 95% CI: 0.63-1.04; p = 0.093) and female gender was not a significant predictor for mortality in IPF (HR 0.74; 95% CI: 0.54-1.03; p = 0.071). Interestingly, the GAP score underestimated the observed 2-year and 3-year mortality in females in GAP stage II. Conclusion: In the German INSIGHTS-IPF registry, no differences in lung function decline and survival could be observed between female and male patients with IPF, indicating differences between IPF cohorts from the USA and Europe.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Idiopathic pulmonary fibrosis; Gender; Interstitial lung disease; Comorbidities; Gender-age-physiology index; Idiopathic Pulmonary-fibrosis; Clinical-practice; Management; Diagnosis; Disease; Adults; Index
ISSN (print) / ISBN 0025-7931
e-ISSN 1423-0356
Zeitschrift Respiration
Verlag Karger
Verlagsort Allschwilerstrasse 10, Ch-4009 Basel, Switzerland
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Lung Health and Immunity (LHI)
Förderungen GWT-TUD GmbH
Boehringer-Ingelheim GmbH