PuSH - Publikationsserver des Helmholtz Zentrums München

Mühleisen, T.W.* ; Mattheisen, M.* ; Strohmaier, J.* ; Degenhardt, F.* ; Priebe, L.* ; Schultz, C.C.* ; Breuer, R.* ; Meier, S.* ; Hoffmann, P.* ; Rivandeneira, F.* ; Hofman, A.* ; Uitterlinden, A.G.* ; Moebus, S.* ; Gieger, C. ; Emeny, R.T. ; Ladwig, K.-H. ; Wichmann, H.-E. ; Schwarz, M.* ; Kammerer-Ciernioch, J.* ; Schlösser, R.G.M.* ; Nenadic, I.* ; Sauer, H.* ; Mössner, R.* ; Maier, W.* ; Rujescu, D.* ; Lange, C.* ; Ophoff, R.A.* ; Schulze, T.G.* ; Rietschel, M.* ; Nöthen, M.M.* ; Cichon, S.*

Association between schizophrenia and common variation in neurocan (NCAN), a genetic risk factor for bipolar disorder.

Schizophr. Res. 138, 69-73 (2012)
DOI PMC
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
A recent study found genome-wide significant association between common variation in the gene neurocan (NCAN, rs1064395) and bipolar disorder (BD). In view of accumulating evidence that BD and schizophrenia partly share genetic risk factors, we tested this single-nucleotide polymorphism for association with schizophrenia in three independent patient-control samples of European ancestry, totaling 5061 patients and 9655 controls. The rs1064395 A-allele, which confers risk for BD, was significantly over-represented in schizophrenia patients compared to controls (p=2.28x10(-3); odds ratio=1.11). Follow-up in non-overlapping samples from the Schizophrenia Psychiatric GWAS Consortium (5537 patients, 8043 controls) provided further support for our finding (p=0.0239, odds ratio=1.07). Our data suggest that genetic variation in NCAN is a common risk factor for BD and schizophrenia.
Altmetric
Weitere Metriken?
[➜Einloggen]
Zusatzinfos bearbeiten [➜Einloggen]
Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Korrespondenzautor
Schlagwörter Association; Genetic Overlap; Manic Depression; Psychotic Disorder; Cortex; Hippocampus
ISSN (print) / ISBN 0920-9964
e-ISSN 1573-2509
Zeitschrift Schizophrenia Research
Quellenangaben Band: 138, Heft: 1, Seiten: 69-73 Artikelnummer: , Supplement: ,
Verlag Elsevier
Verlagsort Amsterdam
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Epidemiology II (EPI2)
Institute of Epidemiology (EPI)
Institute of Genetic Epidemiology (IGE)