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Deshmukh, P.P.* ; Salunkhe, S.S.* ; Shelar, D. ; Dhavan, P.P.* ; Jadhav, B.L.* ; Chavan, A.S.* ; Manjare, S.T.*

Bis(p-formyl-phenyl)diselenide functionalized BODIPY sensor for sensitive recognition of superoxide anion and its biological study.

Main Group Chem., DOI: 10.1177/10241221261441531 (2026)
DOI
An organo-diselenide functionalized BODIPY probe was synthesized and its structure was confirmed through NMR spectroscopic analysis, including (1H, 13C and 77Se) along with mass spectrometric analysis. The reactivity of probe with various Reactive Oxygen Species (ROS) and biologically relevant thiols was systematically investigated. The probe selectively detect superoxide via "turn-off" fluorescence response with a detection limit of 9.65 & micro;M. The probe exhibited quick fluorescence quenching response towards superoxide anion without interference from other ROS and biothiols. Further, in addition to sensing capability, the probe was examined for biological activities, and was displayed significant antibacterial and anti-inflammatory properties, highlighting its potential applicability in both chemical sensing and biomedical studies.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Organoselenium; BODIPY; Superoxide; Antibacterial activity; Anti-inflammatory activity; Reversible Fluorescent-probe; Peroxidase-like Activity; Glutathione-peroxidase; Organoselenium Compounds; In-vitro; Selenium; Peroxynitrite; Derivatives; Diselenide; Toxicology
ISSN (print) / ISBN 1024-1221
e-ISSN 1745-1167
Zeitschrift Main Group Chemistry
Verlag Sage
Verlagsort 2455 Teller Rd, Thousand Oaks, Ca 91320 Usa
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Biological and Medical Imaging (IBMI)
Förderungen University Grant Commission