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Rodriguez-Calvo, T. ; Martinez-Sanchez, A.*

miRNAs in islet biology and diabetes: Progress, gaps, and opportunities.

Diabetes 75, 1052-1066 (2026)
DOI PMC
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
This perspective marks the commemoration of the 2024 Nobel Prize in Medicine for miRNA discovery and reflects on more than two decades of research linking miRNAs to islet biology and diabetes. We very briefly summarize key roles of islet miRNAs in β-cell development, function, and immune interactions and identify major gaps in current knowledge. We discuss emerging concepts in miRNA regulation, cellular heterogeneity, and therapeutic targeting, alongside ongoing challenges in biomarker validation. Our view underscores that integrating mechanistic, single-cell, and translational approaches will be essential to advance miRNA-based therapies.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Review
Schlagwörter Pluripotent Stem-cells; Insulin-producing Cells; Pancreatic Beta-cells; Differentiation; Expression; Mir-375; Mirna; Overexpression; Induction; Expansion
ISSN (print) / ISBN 0012-1797
e-ISSN 1939-327X
Zeitschrift Diabetes
Quellenangaben Band: 75, Heft: 7, Seiten: 1052-1066 Artikelnummer: , Supplement: ,
Verlag American Diabetes Association
Verlagsort Alexandria, VA.
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Diabetes Research (IDF)
Förderungen Medical Research Council10.13039/501100000265
Steve Morgan Foundation - Diabetes UK
Breakthrough T1D
Diabetes UK10.13039/501100000361