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Rodriguez-Calvo, T. ; Martinez-Sanchez, A.*

miRNAs in islet biology and diabetes: Progress, gaps, and opportunities.

Diabetes, DOI: 10.2337/db25-0977 (2026)
DOI PMC
This perspective marks the commemoration of the 2024 Nobel Prize in Medicine for miRNA discovery and reflects on more than two decades of research linking miRNAs to islet biology and diabetes. We very briefly summarize key roles of islet miRNAs in β-cell development, function, and immune interactions and identify major gaps in current knowledge. We discuss emerging concepts in miRNA regulation, cellular heterogeneity, and therapeutic targeting, alongside ongoing challenges in biomarker validation. Our view underscores that integrating mechanistic, single-cell, and translational approaches will be essential to advance miRNA-based therapies.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Review
ISSN (print) / ISBN 0012-1797
e-ISSN 1939-327X
Zeitschrift Diabetes
Verlag American Diabetes Association
Verlagsort Alexandria, VA.
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Diabetes Research (IDF)