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Semenova, A. ; Poor, T.A.* ; Müller-Reif, J.B.* ; Prakki, S.R.S. ; Geyer, P.* ; Mück-Häusl, M. ; Grant, R.A.* ; Rasmussen, L.* ; Holdt, L.* ; Teupser, D.* ; Mann, M.* ; Yildirim, A.Ö. ; Wunderink, R.G.* ; Misharin, A.* ; Singer, B.D.* ; Budinger, G.S.* ; Kapellos, T. ; Schiller, H.B.

Longitudinal clinical proteomics reveals pneumonia type–specific protein biomarkers and autoantibodies.

JCI insight 11:e203056 (2026)
Verlagsversion Forschungsdaten DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
Community-acquired pneumonia is a major cause of morbidity and mortality globally. Specific molecular endotypes are currently not well defined, and different viral or bacterial pathogens may trigger specific host responses and pathogenic mechanisms. We performed longitudinal proteomic profiling of bronchoalveolar lavage fluid and plasma from bacterial, influenza, and SARS-CoV-2-driven pneumonia. Our analysis revealed highly pneumonia type-specific proteomic signatures, including COVID-19-specific antibodies locally produced in the lung. These antibodies showed biased immunoglobulin V-domain usage, linked to a CD69/CD83 plasma cell state associated with disease severity and degree of autoimmunity. Using mass spectrometry-driven autoantibody profiling in 2 independent COVID-19 cohorts, we identified 177 putative autoantibodies targeting extracellular matrix, nuclear, and immune-related proteins. Of note, temporal changes in autoantibody profiles correlated with clinical markers of inflammation, organ dysfunction, and duration of hospitalization. These findings highlight the autoimmune aspects of COVID-19 and provide potential biomarkers and therapeutic targets to help improve patient outcomes.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Autoantibody ; Antibody ; Proteomics ; Bronchoalveolar Lavage ; Pneumonia ; Immunoglobulin G ; Proteome
ISSN (print) / ISBN 2379-3708
e-ISSN 2379-3708
Zeitschrift JCI insight
Quellenangaben Band: 11, Heft: 11, Seiten: , Artikelnummer: e203056 Supplement: ,
Verlag Clarivate
Verlagsort Ann Arbor, Michigan
Begutachtungsstatus Peer reviewed
Institut(e) Research Unit Precision Regenerative Medicine (PRM)
Institute of Lung Health and Immunity (LHI)