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A comprehensive assessment of lifecourse and mortality of Parkinson’s disease in the German National Cohort.
npj Parkinsons Dis. 12:156 (2026)
A strong increase in the prevalence and deaths of Parkinson's disease (PD) has been reported over the last three decades. Ageing societies, genetic and environmental factors and access to health care contribute to these increases. Using data of the German National Cohort (NAKO) PD classifications based on self-report, claims data and a brief medication based algorithm to increase validity in the absence of neurologic examinations, were compared and the PD incidence, selected non-motor symptoms, functions and vital status were analysed. The algorithm based PD prevalence among 205.000 participants was 0.13% but it was 2.5-fold higher in claims data. Self-reported PD incidence was 0.13% over a median of 4.8 years follow-up, but cases had a 4-fold higher mortality, worse emotional, motoric and olfactory functions and higher prevalences of diabetes, obesity, depression and anxiety. The algorithm based PD prevalence and the mortality risk was similar to considerable older population studies from Europe.
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Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Wissenschaftlicher Artikel
Schlagwörter
Cohort ; German ; Disease ; Incidence (geometry) ; Depression (economics) ; Cohort Effect ; Cohort Study ; Population; Diagnostic-criteria; Older; Resistance; Disorders; Features; Trial
ISSN (print) / ISBN
2373-8057
e-ISSN
2373-8057
Zeitschrift
npj Parkinson's Disease
Quellenangaben
Band: 12,
Heft: 1,
Artikelnummer: 156
Verlag
Springer
Verlagsort
Heidelberger Platz 3, Berlin, 14197, Germany
Begutachtungsstatus
Peer reviewed
Institut(e)
Institute of Epidemiology (EPI)
Förderungen
Projekt DEAL