PuSH - Publikationsserver des Helmholtz Zentrums München

Delgado De La Herran, H.C. ; Feng, M. ; Chudenkova, M. ; Perocchi, F.

The mitochondrial calcium uniporter: From parts to signaling networks.

Cold Spring Harbor Perspect. Biol., DOI: 10.1101/cshperspect.a041770 (2026)
DOI PMC
Free by publisher: Verlagsversion online verfügbar 07/2028
Mitochondria act as dynamic signaling hubs, constantly adapting to tissue-specific metabolic demands to ensure cell homeostasis. Central to this role is their capacity to take up calcium (Ca2+) into the matrix, a process that regulates energy production, cell death pathways, and broader cellular signaling. For decades, mitochondrial Ca2+ (mt-Ca2+) uptake was firmly established at the physiological level, yet the identity of the proteins involved remained elusive. The breakthrough discovery of the mitochondrial calcium uniporter complex (MCUC) has finally enabled genetic dissection of mt-Ca2+ fluxes and revealed its pivotal role in health and disease. Here, we retrace the trajectory of the field from the pioneering observations of the 1960s to the molecular era of the MCUC, emphasizing the latest advances in its regulation, integration into cellular networks, and pharmacological targeting.
Altmetric
Weitere Metriken?
[➜Einloggen]
Zusatzinfos bearbeiten [➜Einloggen]
Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Calcium Signaling ; Signal Transduction ; Calcium ; Mitochondrion ; Cell Signaling
e-ISSN 1943-0264
Zeitschrift Cold Spring Harbor Perspectives in Biology
Verlag Cold Spring Harbor Laboratory Press
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Diabetes and Obesity (IDO)