PuSH - Publikationsserver des Helmholtz Zentrums München

Schrenk, M.* ; Nowak, E.* ; Vogel, F.* ; Krüger, L.* ; Stüfchen, I.* ; Oettle, M.* ; Apaydin, T.* ; Bobrowicz, M.* ; Bidlingmaier, M.* ; García-Angarita, N.* ; Hofmann, S.M. ; Dinges, S.M.-T. ; Reisch, N.* ; Siebenbürger, G.* ; Halle, M.* ; Reincke, M.* ; Schoser, B.*

Myopathy in endogenous Cushing’s Syndrome: Type II muscle fiber atrophy and its association with age and circulating IGF-1.

Endocr. Connect., DOI: 10.1530/ec-26-0355 (2026)
Postprint DOI
Open Access Green
Context Patients with endogenous Cushing syndrome (CS) exhibit reduced muscle strength compared with healthy individuals and frequently experience a further postoperative decline despite remission. Objective To evaluate the histological and immunohistochemical patterns underlying myopathy in patients with active and remitted CS. Patients and methods We included nine patients with active CS and eight patients with CS in remission, prospectively enrolled at XXX Hospital. Patients in remission had curative tumor surgery and biochemical remission for ≥24 months. Biopsies of the vastus lateralis muscle were obtained surgically and analyzed by histology, immunohistochemistry, and electron microscopy. IGF-1 concentrations were determined by IDS-iSYS analyzer. Results In active CS, the mean cross-sectional area of type II muscle fibers was reduced. Nicotinamide-adenine-dinucleotide staining revealed mild moth-eaten fiber patterns in four patients, accompanied by ultrastructural pathologies on electron microscopy, including increased subsarcolemmal mitochondrial aggregates that were also present in remitted CS. In active CS circulating absolute IGF-1 concentrations positively (rs=0.8, p=0.014) and age inversely (rs= -0.77, p=0.021) correlated with mean cross-sectional area of type II muscle fibers. In remission from CS, type II fiber atrophy was not present in most patients. No substantial associations were found between the severity of glucocorticoid-excess and histological alterations during active or remitted disease. Conclusion Active CS is characterized by type II fiber atrophy and is associated with circulating IGF-1 and age. In remission type II fiber atrophy was not present, whereas mitochondrial ultrastructural alterations could be observed. These findings indicate sustained muscle alterations and highlight the need for mechanistic studies to guide targeted therapies.
Altmetric
Weitere Metriken?
[➜Einloggen]
Zusatzinfos bearbeiten [➜Einloggen]
Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Atrophy ; Myopathy ; Context (archaeology) ; Vastus Lateralis Muscle ; Immunohistochemistry ; Muscle Atrophy ; Mitochondrial Myopathy ; Skeletal Muscle
ISSN (print) / ISBN 2049-3614
e-ISSN 2049-3614
Zeitschrift Endocrine Connections
Verlag BioScientifica
Verlagsort Bristol
Institut(e) Institute of Diabetes and Regeneration Research (IDR)