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Damirov, F.* ; Ke, J.* ; Karimbayli, J.* ; Stoleriu, M.-G. ; Dreher, S.* ; Boedeker, E.* ; Gerz, S.* ; Hatz, R.* ; Preissler, G.*

Major postoperative complications and survival after lung cancer resection in patients aged ≥80 years: Risk factor analysis.

Curr. Oncol. 33:405 (2026)
Verlagsversion DOI
Open Access Gold
Creative Commons Lizenzvertrag
This study aimed to identify risk factors for major postoperative complications (TMM) and their impact on overall survival in patients aged ≥80 years undergoing lung cancer surgery, a group at increased risk of morbidity. A total of 88 patients aged ≥80 years who underwent anatomical lung resections were retrospectively analyzed. Postoperative complications were classified into minor or no complications (TMM 0–2) and major (TMM ≥ 3) complications. Logistic regression analysis was performed to identify independent predictors of major complications. Kaplan–Meier estimates were used to measure overall survival. Major complications occurred in 24 patients (27.3%). Multivariable regression analysis identified perioperative blood transfusion as an independent risk factor for major complications (p = 0.0009). Patients with major complications exhibited significantly reduced overall survival (p = 0.0009). Subgroup analysis revealed that patients who underwent minimally invasive surgery had significantly better survival (p = 0.01). Moreover, perioperative transfusion correlated with diminished overall survival (p = 0.0027). In patients aged ≥80 years undergoing lung resections, the occurrence of major postoperative complications is associated with significantly impaired survival. Minimally invasive surgical approaches and blood conservation strategies may mitigate complications and enhance long-term outcomes in this high-risk group.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Perioperative ; Lung Cancer ; Logistic Regression ; Risk Factor ; Blood Transfusion ; Proportional Hazards Model ; Subgroup Analysis ; Survival Analysis
ISSN (print) / ISBN 1198-0052
e-ISSN 1718-7729
Zeitschrift Current Oncology
Quellenangaben Band: 33, Heft: 7, Seiten: , Artikelnummer: 405 Supplement: ,
Verlag MDPI
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Lung Health and Immunity (LHI)