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Abdollahi, H.* ; Ahookhosh, K.* ; Nabaei, M.* ; Farnoud, A.

Optimizing inhalation therapy: A computational investigation of ellipsoidal particles in dry powder inhalers.

Comp. meth. biomech. biomed. engin. imag. visual., DOI: 10.1080/10255842.2026.2704680 (2026)
DOI
Targeted drug delivery seeks to maximize drug deposition in specific respiratory regions while minimizing undesired deposition. This study numerically investigated micron-sized particle deposition in a realistic human tracheobronchial model using an Eulerian–Lagrangian approach. Ellipsoidal particles with a fixed minor axis of 3.6 μm and aspect ratios of 1–10 were analyzed at inhalation flow rates of 30, 60, and 90 L/min. Compared with spherical particles, ellipsoidal particles reduced mouth–throat deposition and enhanced penetration into deeper lungs. At 60 L/min, particles with an aspect ratio of 3 increased deep-lung penetration by 6%, demonstrating their potential for targeted pulmonary drug delivery.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Computational Fluid Dynamics (cfd) ; Ellipsoidal Particle ; Human Respiratory System ; Particle Deposition ; Pulmonary Drug Delivery; Air-flow; Aerosol Deposition; Human Lung; Realistic Model; Simulation; Delivery; Fraction; Laminar; Fibers; Fluid
ISSN (print) / ISBN 2168-1163
e-ISSN 2168-1171
Zeitschrift Computer methods in biomechanics and biomedical engineering : imaging & visualization
Verlag Taylor & Francis
Verlagsort Abingdon
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Computational Biology (ICB)
Förderungen Center for International Scientific Studies and Collaboration (CISSC) of the Ministry of Science, Research and Technology of Iran