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A lipid kinase joins the transcriptional machinery.
Nat. Cell Biol., DOI: 10.1038/s41556-026-02046-z (2026)
Long recognized for its roles in autophagy and endosomal trafficking, phosphatidylinositol 3-kinase class III (PI3K-3) is now shown to also function in the nucleus. A recent study shows that PI3K-3 associates with the transcriptional machinery and a chromatin-modifying complex, and contributes to transcriptional adaptation during fasting.
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Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Fachkommentar, Meinungsartikel
Schlagwörter
Phosphatidylinositol ; Autophagy ; Function (biology) ; Kinase ; Endosome ; Transcriptional Regulation
ISSN (print) / ISBN
1465-7392
e-ISSN
1476-4679
Zeitschrift
Nature Cell Biology
Verlag
Nature Publishing Group
Verlagsort
Heidelberger Platz 3, Berlin, 14197, Germany
Begutachtungsstatus
Peer reviewed
Institut(e)
Institiute of Functional Epigenetics (IFE)
Förderungen
Deutsche Forschungsgemeinschaft (German Research Foundation)