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Termorshuizen, J.D.* ; Davies, H.L.* ; Lee, S.H.* ; Dennis, J.K.* ; Hübel, C.* ; Johnson, J.S.* ; Lu, Y.* ; Munn‐Chernoff, M.A.* ; Peters, T.* ; Qi, B.* ; Schaumberg, K.E.* ; Signer, R.* ; Singh, K.* ; Kuile, A.t.* ; Thornton, L.M.* ; Xu, J.* ; Yao, S.* ; Yılmaz, Z.* ; Zhang, R.* ; Zvrskovec, J.* ; Abdulkadir, M.* ; Ayorech, Z.* ; Corfield, E.C.* ; Havdahl, A.* ; Krebs, K.* ; Mack, T.* ; Niarchou, M.* ; Palviainen, T.* ; Sealock, J.* ; Baker, J.H.* ; Bergen, A.W.* ; Birgegård, A.* ; Perica, V.B.* ; Bühren, K.* ; Burghardt, R.* ; Cassina, M.* ; Castellini, G.* ; Collantoni, E.* ; Crowley, J.J.* ; Danner, U.N.* ; Degenhardt, F.* ; DeSocio, J.* ; Dina, C.* ; Dmitrzak‐Węglarz, M.* ; Duncan, L.E.* ; Egberts, K.* ; Foretová, L.* ; Giegling, I.* ; Gonidakis, F.* ; Gordon, S.D.* ; Grove, J.* ; Guillaume, S.* ; Guintivano, J.D.* ; Hartmann, A.M.* ; Hatzikotoulas, K. ; Herms, S.* ; Imgart, H.* ; Jiménez-Murcia, S.* ; Julià, A.* ; Kalsi, G.* ; Kaminská, D.* ; Karhunen, L.* ; Kennedy, H.* ; Kiezebrink, K.M.* ; Kolb, T.* ; Larsen, J.T.* ; Li, D.* ; Lilenfeld, L.* ; Maj, M.* ; Mattingsdal, M.* ; Meneguzzo, P.* ; Miller, A.L.* ; Mitchell, K.S.* ; Monteleone, A.M.* ; Olsen, C.M.* ; Padyukov, L.* ; Parker, R.* ; Pettie, M.* ; Pinto, D.* ; Raevuori, A.* ; Ripatti, S.* ; Roberts, M.* ; Santonastaso, P.* ; Savva, A.* ; Schmidt, U.H.* ; Schosser, A.* ; Seitz, J.* ; Lenka Šlachtová,* ; Slopien, A.* ; Sorbi, S.* ; Straub, P.* ; Szatkiewicz, J.* ; Tam, F.I.* ; Tenconi, E.* ; Tortorella, A.* ; Tsitsika, A.* ; Elburg, A.* ; Wagner, G.* ; Watson, H.J.* ; Adan, R.A.*

Genomic meta-analyses of binge-eating behavior and anorexia nervosa yield insights into the unique and shared biology of eating disorder phenotypes.

Nat. Ment. Health, DOI: 10.1038/s44220-026-00698-2 (2026)
Verlagsversion Forschungsdaten DOI
Open Access Hybrid
Creative Commons Lizenzvertrag
Eating disorders—including anorexia nervosa (AN), bulimia nervosa and binge-eating disorder—are clinically distinct but exhibit symptom overlap and diagnostic crossover. Genomic analyses have mostly examined AN. Here we conducted a genomic meta-analysis of case–control studies of binge-eating behavior (BE; 39,279 cases, 1,227,436 controls), alongside analyses of AN (24,223 cases, 1,243,971 controls) and its subtypes (all European ancestries). We identified six BE-associated loci, including loci associated with a higher body mass index and impulse-control behaviors. AN genome-wide association studies yielded eight loci, validating six loci. Subsequent polygenic risk score analysis demonstrated an association with AN in two East Asian ancestry studies. BE and AN exhibited similar positive genetic correlations with psychiatric disorders but opposing genetic correlations with anthropometric traits. Most of the genetic signal in BE and AN was not shared with body mass index. We have extended eating disorder genomics beyond AN; future work will incorporate multiple diagnoses and global ancestries.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Anorexia Nervosa ; Bulimia Nervosa ; Body Mass Index ; Eating Disorders ; Genome-wide Association Study ; Phenotype ; Genomics ; Anthropometry ; Genetic Association
ISSN (print) / ISBN 2731-6076
e-ISSN 2731-6076
Zeitschrift Nature Mental Health
Verlag Nature Publishing Group
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Translational Genetics (ITG)