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Oluwagbemigun, K.* ; Ziegler, D.* ; Strom, A.* ; Heier, M. ; Bonhof, G.J.* ; Roden, M.* ; Rathmann, W.* ; Meisinger, C.* ; Peters, A. ; Hauck, S.M. ; Petrera, A. ; Sinner, M.F.* ; Kaab, S.* ; Thorand, B. ; Herder, C.*

Differential associations of resting heart rate and heart rate variability indices with cardiovascular and coronary heart disease mortality risk: The prospective KORA study.

Sci. Rep. 16:26028 (2026)
Verlagsversion Forschungsdaten DOI
Open Access Gold
Creative Commons Lizenzvertrag
Limited data exist on the relationship of resting heart rate (RHR) and heart rate variability (HRV) indices with cardiovascular (CVD) and coronary heart disease (CHD) mortality in individuals with and without (pre)diabetes. We investigated overall and glucose tolerance status-specific association of RHR and a large number of HRV indices with incident long-term CVD and CHD mortality. RHR and 66 HRV indices were obtained from five-minute electrocardiogram performed at baseline (KORA S4; 1999-2001) in 1390 adults from the prospective Cooperative Health Research in the Region of Augsburg (KORA). CVD and CHD mortality were ascertained over a 22-year follow-up. Linear and non-linear association of RHR and indices with mortality in the overall sample and normal glucose tolerance (NGT), prediabetes and type 2 diabetes subsamples were determined using Cox models. Independent of covariates, RHR was directly associated with CVD (1.20 [1.04, 1.39], P = 0.013) and CHD (1.32 [1.08, 1.62], P = 0.007) mortality in the overall study sample. Additionally, very-low frequency power (VLF) was directly associated with CVD mortality (1.17 [1.01, 1.37]; P = 0.038) in NGT. Square root of the mean squared differences of successive NN intervals (RMSSD) showed non-linear association with CVD mortality in type 2 diabetes. Number of data points in the 8th column of a 12 & times; 12 matrix (SPPA_c_8) was inversely associated with CVD mortality (0.54 [0.32, 0.93], P = 0.025) in prediabetes. These findings suggest that RHR and HRV indices provide differential and complementary insights into long-term CVD mortality risk in the general population.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Resting heart rate; Heart rate variability indices; Cardiovascular disease mortality risk; Coronary heart disease mortality risk; Glucose tolerance status; Normal glucose tolerance; Prediabetes; Type 2 diabetes; Cardiac Autonomic Dysfunction; Independent Predictor; Elderly Population; General-population; Qt Interval; All-cause; Individuals; Health
ISSN (print) / ISBN 2045-2322
e-ISSN 2045-2322
Zeitschrift Scientific Reports
Quellenangaben Band: 16, Heft: 1, Seiten: , Artikelnummer: 26028 Supplement: ,
Verlag Springer
Verlagsort London
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Epidemiology (EPI)
Core Facility Metabolomics and Proteomics (CF-MPC)
Förderungen Universittsklinikum Dsseldorf. Anstalt ffentlichen Rechts (8911)