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Kovács, M.G.* ; Goncalves, A.I.A.* ; Varga, Z.* ; Losonczi, R.* ; Kupecz, K.* ; Volford, D.* ; Pósa, S.P.* ; Minorics, R.* ; Galla, Z.* ; Zins, K.* ; Sejben, A.* ; Kriston, A.* ; Kovács, F.* ; Horvath, P. ; Monostori, P.B.* ; Cserni, G.* ; Zupkó, I.* ; Podesser, B.K.* ; Barnea, E.R.* ; Kahán, Z.* ; Kiss, A.* ; Pokreisz, P.* ; Sárközy, M.*

Synthetic preimplantation factor ameliorates the severity of radiotherapy-induced heart disease in a rat model.

Front. Cardiovasc. Med. 13:1946843 (2026)
Verlagsversion DOI
Open Access Gold
Creative Commons Lizenzvertrag
Background: Radiation-induced heart disease (RIHD) is a potential side effect of radiotherapy (RT) for thoracic tumors and breast cancers, often causing diastolic dysfunction, left ventricular hypertrophy (LVH), and fibrosis. Preimplantation factor (PIF), an embryonic immunomodulatory peptide, has shown protective effects against acute radiation syndrome. We investigated whether synthetic PIF (sPIF) could mitigate RIHD development in rats and tumor cell proliferation in human breast cancer cell lines.Methods: Adult male Sprague-Dawley rats were allocated into three experimental groups: vehicle-treated control, vehicle-treated RT (50 Gy, focused on the heart), and RT treated with sPIF, monitored at 1, 3, and 15 weeks. Endpoint assessments included transthoracic echocardiography, histopathology, qPCR, Western blotting, and UHPLC–MS/MS in the left ventricular (LV) samples. The effects of sPIF on hypertrophy, fibrosis, and proliferation were investigated in H9c2 cardiomyoblasts, human ventricular cardiac fibroblasts (HVCFs), and human breast carcinoma cells, respectively.Results: sPIF decreased LV expression of inflammatory markers at week 3 and attenuated RT-induced LVH and fibrosis, with reduced nitrotyrosine accumulation at week 15. sPIF suppressed angiotensin II–induced hypertrophy in H9c2 cells, inhibited transforming growth factor-β1 (TGFβ1)–induced collagen-1 expression in HVCFs, and enhanced the anti-proliferative response to RT in human breast carcinoma cells.Conclusions: These findings suggest the potential of sPIF as a cardioprotective agent for the management of RIHD and warrant further mechanistic investigations.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
ISSN (print) / ISBN 2297-055X
e-ISSN 2297-055X
Zeitschrift Frontiers in Cardiovascular Medicine
Quellenangaben Band: 13, Heft: , Seiten: , Artikelnummer: 1946843 Supplement: ,
Verlag Frontiers
Verlagsort Lausanne
Begutachtungsstatus Peer reviewed
Institut(e) Institute of AI for Health (AIH)