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Bastian, L.* ; Kurz, E.M.* ; Gutjahr, L.* ; Noack, H.* ; Born, J.

Sleep forms flexible context representations in toddlers.

Nat. Commun. 17:10699 (2026)
Verlagsversion Forschungsdaten DOI
Open Access Gold
Creative Commons Lizenzvertrag
Sleep consolidates episodic memory through a hippocampus-dependent process in adults. Whether and how sleep supports memory consolidation during early life, when hippocampal function is immature, remains unclear. Here, we examined effects of sleep on the consolidation of spatial context, a core component of episodic memory, in toddlers aged 2–3 years. Toddlers were familiarized with two spatial contexts, followed by a ~ 90-min nap or equivalent wake period. Afterwards, using a hide-and-seek game we tested their ability to relocate toys within these contexts. Only after post-familiarization sleep, toddlers showed significant context memory and formed stronger associations between toys and specific contexts compared to wakefulness. Contextual memory was positively correlated with spindle density and slow oscillation–spindle phase-amplitude coupling during non-rapid eye movement sleep. Here, we show that, despite hippocampal immaturity, memory effects in the sleeping toddler’s brain are accompanied by thalamo-cortical oscillatory dynamics that are also implicated in adult memory consolidation.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
ISSN (print) / ISBN 2041-1723
e-ISSN 2041-1723
Zeitschrift Nature Communications
Quellenangaben Band: 17, Heft: 1, Seiten: , Artikelnummer: 10699 Supplement: ,
Verlag Springer
Verlagsort London
Begutachtungsstatus Peer reviewed
Institut(e) Institute for Diabetes Research and Metabolic Diseases (IDM)