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Rathmann, W.* ; Kowall, B.* ; Tamayo, T.* ; Giani, G.* ; Holle, R. ; Thorand, B. ; Heier, M. ; Huth, C. ; Meisinger, C.

Hemoglobin A1c and glucose criteria identify different subjects as having type 2 diabetes in middle-aged and older populations: The KORA S4/F4 study.

Ann. Med. 44, 170-177 (2012)
DOI PMC
Open Access Gold möglich sobald Verlagsversion bei der ZB eingereicht worden ist.
Objective. The American Diabetes Association (ADA) has recently recommended HbA1c for diagnosing diabetes as an alternative to glucose-based criteria. We compared the new HbA1c-based criteria for diagnosis of diabetes and prediabetes with the glucose-based criteria. Research design and methods. In the population-based German KORA surveys (S4/F4) 1,764 non-diabetic participants aged 31-60 years and 896 participants aged 61-75 years underwent measurements of HbA1c, fasting plasma glucose (FPG), and 2-h glucose. Results. Only 20% of all subjects diagnosed with diabetes by glucose or HbA1c criteria had diabetes by both criteria; for prediabetes, the corresponding figure was 23%. Using HbA1c >= 6.5%, the prevalence of diabetes was strongly reduced compared to the glucose criteria (0.7% instead of 2.3% in the middle-aged, 2.9% instead of 7.9% in the older subjects). Only 32.0% (middle-aged) and 43.2% (older group) of isolated impaired glucose tolerance (i-IGT) cases were detected by the HbA1c criterion (5.7% <= HbA1c < 6.5%). Conclusion. By glucose and the new HbA1c diabetes criteria, different subjects are diagnosed with type 2 diabetes in middle-aged as well as older subjects. The new HbA1c criterion lacks sensitivity for impaired glucose tolerance.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Korrespondenzautor
Schlagwörter Glycosylated Hemoglobin A ; Impaired Fasting Glucose ; Impaired Glucose Tolerance ; Normal Glucose Tolerance ; Oral Glucose Tolerance Test ; Type 2 Diabetes Mellitus; INSULIN-RESISTANCE ATHEROSCLEROSIS; GLYCATED HEMOGLOBIN; LIFE-STYLE; MELLITUS; PREVALENCE; DIAGNOSIS; TOLERANCE; RISK; PERFORMANCE; IMPACT
ISSN (print) / ISBN 0785-3890
e-ISSN 1365-2060
Zeitschrift Annals of Medicine
Quellenangaben Band: 44, Heft: 2, Seiten: 170-177 Artikelnummer: , Supplement: ,
Verlag Informa Healthcare
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Epidemiology II (EPI2)
Institute of Health Economics and Health Care Management (IGM)