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Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Nasal insulin changes peripheral insulin sensitivity simultaneously with altered activity in homeostatic and reward-related human brain regions.
Diabetologia 55, 1773-1782 (2012)
Impaired insulin sensitivity is a major factor leading to type 2 diabetes. Animal studies suggest that the brain is involved in the regulation of insulin sensitivity. We investigated whether insulin action in the human brain regulates peripheral insulin sensitivity and examined which brain areas are involved. Insulin and placebo were given intranasally. Plasma glucose, insulin and C-peptide were measured in 103 participants at 0, 30 and 60 min. A subgroup ( = 12) was also studied with functional MRI, and blood sampling at 0, 30 and 120 min. For each time-point, the HOMA of insulin resistance (HOMA-IR) was calculated as an inverse estimate of peripheral insulin sensitivity. Plasma insulin increased and subsequently decreased. This excursion was accompanied by slightly decreased plasma glucose, resulting in an initially increased HOMA-IR. At 1 h after insulin spray, the HOMA-IR subsequently decreased and remained lower up to 120 min. An increase in hypothalamic activity was observed, which correlated with the increased HOMA-IR at 30 min post-spray. Activity in the putamen, right insula and orbitofrontal cortex correlated with the decreased HOMA-IR at 120 min post-spray. Central insulin action in specific brain areas, including the hypothalamus, may time-dependently regulate peripheral insulin sensitivity. This introduces a potential novel mechanism for the regulation of peripheral insulin sensitivity and underlines the importance of cerebral insulin action for the whole organism.
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Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Wissenschaftlicher Artikel
Schlagwörter
Brain ; Fmri ; Homa ; Hypothalamus ; Insula ; Insulin ; Insulin Sensitivity ; Intranasal Insulin ; Orbitofrontal Cortex ; Putamen; DOSE-RESPONSE CHARACTERISTICS; POSITRON-EMISSION-TOMOGRAPHY; HUMAN ORBITOFRONTAL CORTEX; CENTRAL-NERVOUS-SYSTEM; GLUCOSE-METABOLISM; FUNCTIONAL-ASPECTS; ENERGY-BALANCE; RESISTANCE; BROMOCRIPTINE; EXPRESSION
ISSN (print) / ISBN
0012-186X
e-ISSN
1432-0428
Zeitschrift
Diabetologia
Quellenangaben
Band: 55,
Heft: 6,
Seiten: 1773-1782
Verlag
Springer
Verlagsort
Berlin ; Heidelberg [u.a.]
Begutachtungsstatus
Peer reviewed