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Kriebel, J. ; Grallert, H. ; Illig, T.

Typ-2-Diabetes-assoziierte Gene.

Diabetologie 8, 26-34 (2012)
DOI
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Type 2 diabetes is becoming more and more important because the prevalence of the disease, which is characterized by reduced insulin sensitivity and secretion, keeps rising in the population. This dysfunction leads to a decreased glucose uptake in target tissues, whereby the blood glucose level eventually increases. In this process genetic as well as environmental factors play a role but the fundamental pathogenesis is still not fully understood. Numerous genes contributing to the manifestation have already been identified mainly via genome-wide association studies (GWAS). The main part of the heritability of type 2 diabetes as well as functional mechanisms remain unclear. The elucidation is the first step towards the development of improved as well as personalized therapeutic approaches.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Type 2 Diabetes ; Dna Variant ; Genome-wide Association Study (gwas) ; Therapy ; Gene; GENOME-WIDE ASSOCIATION; RISK; GLUCOSE; VARIANT; LOCI; SUSCEPTIBILITY; PREVENTION; OBESITY; TCF7L2; KCNQ1
Sprache deutsch
Veröffentlichungsjahr 2012
HGF-Berichtsjahr 2012
ISSN (print) / ISBN 2731-7447
e-ISSN 2731-7455
Zeitschrift Diabetologie, Die
Quellenangaben Band: 8, Heft: 1, Seiten: 26-34 Artikelnummer: , Supplement: ,
Verlag Springer
Begutachtungsstatus Peer reviewed
Institut(e) Research Unit Molecular Epidemiology (AME)
POF Topic(s) 30501 - Systemic Analysis of Genetic and Environmental Factors that Impact Health
Forschungsfeld(er) Genetics and Epidemiology
PSP-Element(e) G-504200-002
DOI 10.1007/s11428-011-0779-8
WOS ID WOS:000303234200004
Scopus ID 84858666253
Erfassungsdatum 2012-07-23
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