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Kääb, S.* ; Crawford, D.C.* ; Sinner, M.F.* ; Behr, E.R.* ; Kannankeril, P.J.* ; Wilde, A.A.* ; Bezzina, C.R.* ; Schulze-Bahr, E.* ; Guicheney, P.* ; Bishopric, N.H.* ; Myerburg, R.J.* ; Schott, J.J.* ; Pfeufer, A.* ; Beckmann, B.M.* ; Martens, E.* ; Zhang, T.* ; Stallmeyer, B.* ; Zumhagen, S.* ; Denjoy, I.* ; Bardai, A.* ; van Gelder, I.C.* ; Jamshidi, Y.* ; Dalageorgou, C.* ; Marshall, V.* ; Jeffery, S.* ; Shakir, S.* ; Camm, A.J.* ; Steinbeck, G.* ; Perz, S.* ; Lichtner, P. ; Meitinger, T. ; Peters, A. ; Wichmann, H.-E. ; Ingram, C.* ; Bradford, Y.* ; Carter, S.* ; Norris, K.* ; Ritchie, M.D.* ; George, A.L. Jr.* ; Roden, D.M.*

A large candidate gene survey identifies the KCNE1 D85N polymorphism as a possible modulator of drug-induced torsades de pointes.

Circ. Cardiovasc. Genet. 5, 91-99 (2012)
DOI PMC
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
BACKGROUND: Drug-induced long-QT syndrome (diLQTS) is an adverse drug effect that has an important impact on drug use, development, and regulation. We tested the hypothesis that common variants in key genes controlling cardiac electric properties modify the risk of diLQTS. METHODS AND RESULTS: In a case-control setting, we included 176 patients of European descent from North America and Europe with diLQTS, defined as documented torsades de pointes during treatment with a QT-prolonging drug. Control samples were obtained from 207 patients of European ancestry who displayed <50 ms QT lengthening during initiation of therapy with a QT-prolonging drug and 837 control subjects from the population-based KORA study. Subjects were successfully genotyped at 1424 single-nucleotide polymorphisms (SNPs) in 18 candidate genes including 1386 SNPs tagging common haplotype blocks and 38 nonsynonymous ion channel gene SNPs. For validation, we used a set of cases (n=57) and population-based control subjects of European descent. The SNP KCNE1 D85N (rs1805128), known to modulate an important potassium current in the heart, predicted diLQTS with an odds ratio of 9.0 (95% confidence interval, 3.5-22.9). The variant allele was present in 8.6% of cases, 2.9% of drug-exposed control subjects, and 1.8% of population control subjects. In the validation cohort, the variant allele was present in 3.5% of cases and in 1.4% of control subjects. CONCLUSIONS: This high-density candidate SNP approach identified a key potassium channel susceptibility allele that may be associated with the rare adverse drug reaction torsades de pointes.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Korrespondenzautor
Schlagwörter candidate genes; death, sudden; SNP; torsade de pointes; adverse drug events
ISSN (print) / ISBN 1942-325X
e-ISSN 1942-3268
Zeitschrift Circulation: Cardiovascular Genetics
Quellenangaben Band: 5, Heft: 1, Seiten: 91-99 Artikelnummer: , Supplement: ,
Verlag Lippincott Williams & Wilkins
Verlagsort Hagerstown, Md
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Human Genetics (IHG)
Institute of Epidemiology II (EPI2)
Institute of Epidemiology (EPI)
Institute of Biological and Medical Imaging (IBMI)